Understanding influenza virus-specific epidemiological properties by analysis of experimental human infections

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题名:	Understanding influenza virus-specific epidemiological properties by analysis of experimental human infections
作者:	C.-M.LIAO S.-C.YANG C.-P.CHIO S.-C.CHEN
贡献者:	中山醫學大學公共衛生學系
关键词:	Epidemiology modelling transmission influenza infectiousness
日期:	2009
上传时间:	2012-08-20T07:33:22Z (UTC)
摘要:	This study aimed to estimate the natural history and transmission parameters based on experimental viral shedding and symptom dynamics in order to understand the key epidemiological factors that characterize influenza (sub)type epidemics. A simple statistical algorithm was developed by combining a well-defined mathematical scheme of epidemiological determinants and experimental human influenza infection. Here we showed that (i) the observed viral shedding dynamics mapped successfully the estimated time-profile of infectiousness and (ii) the profile of asymptomatic probability was obtained based on observed temporal variation of symptom scores. Our derived estimates permitted evaluation of relationships between various model-derived and data-based estimations, allowing evaluation of trends proposed previously but not tested fully. As well as providing insights into the dynamics of viral shedding and symptom scores, a more profound understanding of influenza epidemiological parameters and determinants could enhance the viral kinetic studies of influenza during infection in the respiratory tracts of experimentally infected individuals.
URI:	https://ir.csmu.edu.tw:8080/ir/handle/310902500/4478
關聯:	Epidemiology and Infection Volume 138 / Issue 06 / June 2010 , pp 825-835
显示于类别:	[公共衛生學系暨碩士班] 期刊論文

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