|
English
|
正體中文
|
简体中文
|
Items with full text/Total items : 17938/22957 (78%)
Visitors : 7404020
Online Users : 111
|
|
|
Loading...
|
Please use this identifier to cite or link to this item:
https://ir.csmu.edu.tw:8080/ir/handle/310902500/4442
|
Title: | Attenuated Cardiac Mitochondrial-Dependent Apoptotic Effects by Li-Fu Formula in Hamsters Fed with a Hypercholesterol Diet |
Authors: | Kuo, Wei-Wen Hsu, Tsai-Ching Chain, Mei-Haung Lai, Chao-Hung Wang, Wen-Hong Tsai, Fuu-Jen Tsai, Chang-Hai Wu, Chieh-His Huang, Chih-Yang Tzang, Bor-Show |
Contributors: | 中山醫學大學 醫學系 |
Date: | 2009-10-02 |
Issue Date: | 2012-08-10T07:55:44Z (UTC)
|
ISSN: | 1741-427X |
Abstract: | Apoptosis involves in the pathogenesis of various cardiac abnormalities. This study intends to evaluate the effects of Li-Fu formula on cardiac apoptosis induced by hyper-cholesterol diet. Twenty-four male Golden Syrian hamsters were randomly divided into Control, Cholesterol and Li-Fu formula groups. Histopathological analysis, western blotting and terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assays were performed to measure the effects of Li-Fu formula on left ventricle. Significantly reduced TUNEL-positive cells and mitochondria- dependent apoptosis were observed in the left ventricle of hamsters from Li-Fu formula group compared to the Cholesterol group. Additionally, induced cardiac insulin like growth factor I receptor (IGFIR)-dependent survival pathway was detected in the Li-Fu formula group compared to the Cholesterol group. Besides, minor fibrosis, increased collagen deposition, and myofibril disarray was detected in the Cholesterol group, whereas the reductions of collagen deposition and myofibril disarray were observed in the Li-Fu formula group. This study demonstrated that Li-Fu formula not only reduced the mitochondria-dependent apoptosis and fibrosis, but also enhanced the IGF-I survival pathway in the left ventricle from high cholesterol-fed hamsters. We suggest the protective effects of Li-Fu formula on cardiac apoptosis and therapeutic potentials against cardiovascular disease. |
URI: | https://ir.csmu.edu.tw:8080/ir/handle/310902500/4442 http://dx.doi.org/10.1093/ecam/nep182 |
Relation: | Evidence-Based Complementary and Alternative Medicine Volume 2011 (2011), Article ID 530345, 9 pages |
Appears in Collections: | [醫學系] 期刊論文
|
Files in This Item:
File |
Description |
Size | Format | |
index.html | 期刊論文 | 0Kb | HTML | 523 | View/Open |
|
All items in CSMUIR are protected by copyright, with all rights reserved.
|