Comparison of otologic complications between intensity-modulated and two-dimensional radiotherapies in nasopharyngeal carcinoma patients

doi:10.1016/j.otohns.2010.07.012

中山醫學大學機構典藏 CSMUIR > 醫學院 > 醫學系 > 期刊論文 > Item 310902500/4384

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/4384

Title:	Comparison of otologic complications between intensity-modulated and two-dimensional radiotherapies in nasopharyngeal carcinoma patients
Authors:	Hsin, Chung-Han Chen, Tsai-Hsin Young, Yi-Ho Liu, Wen-Shan
Contributors:	中山醫學大學醫學系耳鼻喉科
Date:	2010-07-19
Issue Date:	2012-07-31T07:00:21Z (UTC)
ISSN:	0194-5998
Abstract:	Objective To investigate the otologic complications in patients with nasopharyngeal carcinoma (NPC) who were treated by intensity-modulated radiotherapy (IMRT) and compared with those who were treated by two-dimensional radiotherapy (2DRT). Study Design A historical cohort study was performed comprising NPC patients who underwent IMRT or 2DRT at Chung Shan Medical University Hospital. Setting Chung Shan Medical University Hospital. Subjects and Methods Twenty-six NPC patients treated by IMRT (group A) and 18 NPC patients treated by 2DRT (group B) were enrolled. All patients underwent otoscopy, audiometry, and a vestibular-evoked myogenic potential (VEMP) test at a mean interval of three years after irradiation. Results Although groups A and B did not significantly differ in the occurrence rate of otitis media with effusion (OME), group B had a significantly greater occurrence rate of chronic otitis media than group A (P < 0.05, χ2 test). The incidences of high-frequency sensorineural hearing loss were 46 percent in group A and 67 percent in group B, with no significant difference between the two. In terms of VEMPs, group A had a significantly lower abnormal rate (31%) than group B (61%; P < 0.05, χ2 test). In addition, a significant relationship existed between T stages and OME in NPC patients treated by IMRT (P < 0.01, Fisher-Freeman-Halton test) but not by 2DRT. Conclusion The incidence of chronic otitis media and abnormal VEMPs in NPC patients treated by IMRT were significantly lower when compared with those treated by 2DRT, demonstrating the superiority of IMRT in decreasing unwanted otologic complications. However, occurrence of OME, which was related with advanced T stage, cannot be reduced by IMRT.
URI:	https://ir.csmu.edu.tw:8080/ir/handle/310902500/4384 http://dx.doi.org/10.1016/j.otohns.2010.07.012
Relation:	Otolaryngology - Head and Neck Surgery Volume 143, Issue 5, November 2010, Pages 662–668
Appears in Collections:	[醫學系] 期刊論文

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