中山醫學大學機構典藏 CSMUIR:Item 310902500/4340
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    题名: Flaxseed Oil Attenuates Nonalcoholic Fatty Liver of Hyperlipidemic Hamsters
    作者: Yang, Shun-Fa
    Tseng, Jung-Kai
    Chang, Yuan-Yen
    Chen, Yi-Chen
    贡献者: 中山醫學大學醫學系
    微免學科
    关键词: Flaxseed oil
    hepatic cholesterol/triacylglycerol contents
    GSH
    MDA
    matrix metalloproteinases
    NAFL
    日期: 2009-05-19
    上传时间: 2012-07-20T07:30:33Z (UTC)
    ISSN: 0021-8561
    摘要: Hyperlipidemia of hamsters was induced by high-fat/cholesterol diets formulated by the addition of coconut oil (CO), butter (BU), and flaxseed oil (FX). Lower (p < 0.05) serum lipids, liver size, and hepatic cholesterol and triacylglycerol contents were observed in the FX group compared to both CO and BU groups. The liver damage indices [glutamic oxaloacetic transaminase (GOT) and glutamic pyruvic transaminase (GPT) values] in the FX group were lower (p < 0.05) than those in the CO and BU groups, which may result from higher (p < 0.05) glutathione (GSH) levels and a tendency toward lower malondialdehyde (MDA) levels in livers. Besides, lower (p < 0.05) gene expression and activity of hepatic matrix metalloproteinases-9 (MMP-9) in the FX group were lower (p > 0.05) compared to those in the CO and BU groups; however, no (p > 0.05) differences in gene expression activities of hepatic MMP-2 were observed among treatments. Those beneficial effects could explain the attenuation of FX on nonalcoholic fatty liver (NAFL) induced by a high-fat/cholesterol dietary habit.
    URI: https://ir.csmu.edu.tw:8080/ir/handle/310902500/4340
    http://dx.doi.org/10.1021/jf900499v
    關聯: American Chemical Society
    J. Agric. Food Chem., 2009, 57 (11), pp 5078–5083
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