| 摘要: | 本研究將搭配本校附設醫院之替代?法戒毒門診，深入瞭解患者實際之用藥情形，除檢驗替代藥物及海?因代謝物外，亦檢驗其他可能併用之藥物，以作為評估及個人治?應用。為求分析效?，本研究將發展 LC/MS/MS 廣測方法，透過至少 400件?與替代?法者?液檢體分析，與 75件唾液與毛髮檢體，瞭解患者實際之用藥情形，並探討?同生物檢體之相關性，最後並將分析?液中 8-oxodGuo 的濃?，以評估其體內之氧化性傷害。 ?液檢驗預計初篩藥物有：安非他命?、鴉片?、大麻?、Ketamine?、與苯二氮平?藥物五大?。?液確認分析藥物則包含：安非他命?Amphetamine Methamphet amine）、（MDMA、MDEA、MDA）、鴉片?（Morphine、Codeine、6-acetyl morphine）、大麻代謝物THCA、Ketamine、Norketamine、Methadone、Buprenorphine、新興?用藥物（LSD、PCP、2C-B、2C-C、2C-I、PMA、PMMA、PMEA、Zolipidem、5-MeO-DIPT、5-MeO-AMT、AMT）與苯二氮平?藥物（包含Nimetazepam、Diazepam、Nordiazepam、Temazepam、Oxazepam、Tria zolam、Flunitrazepam、Nitrazepam、Alprazolam、Lorzepam等藥物）。 毛髮與唾液分析藥物包含：安非他命? Amphetamine、Methamphet amine）、（MDMA、MDEA、MDA）、鴉片?（Morphine、Codeine、6-acetyl morphine）、大麻代謝物THCA、Ketamine、Norketamine、Methadone 與苯二氮平?藥物（包含Nimetazepam、Diazepam、Nordiazepam、Temazepam、Oxazepam、Triazolam、Flunitrazepam、Nitrazepam、Alprazolam、Lorzepam 藥物）。
The study will establish deep understanding of drug use in patients for the methadone maintenance therapy patient by urine, oral fluid and hair testing. In addition to the moniter heroin metabolites, also combines with the inspection of other possible drugs, as the application of the assessment and treatment of individualsIn period of two years, inspection and evaluation to participate in the methadone maintenance therapy ethnic staff in urine,oral fluid and hair in is contained in the analysis of drugs, through the participation of at least 400 urines and 75 hair and oral fluid specimens of methadone maintenance therapy, and analysis the urine concentration of 8-oxodGuo, to assess their inner oxidative stress for patient of methadone maintenance therapy. Urine screening test is expected: amphetamine, opiate, ketamine and cannabis. Urine confirmation test contains: amphetamine amphetamine and methamphetamine), (MDMA and MDEA, MDA), opiates (morphine, Codeine, 6-acetylmorphine), cannabis metabolites THCA, aetamine, Norketamine, methadone, emerging drug abuse (LSD, PCP, 2C-B, 2C-C, 2C-I, PMEA, PMA, PMMA and 5-Zolipidem, MeO-DIPT, 5-MeO-AMT, AMT) and drug clozapine class of BZD (containing Nimetazepam, Diazepam, Temazepam, Nordiazepam, Oxazepam, Triazolam, Flunitrazepam, Nitrazepam, Alprazolam, Lorzepam and other drugs). Hair is directly for analysis, analysis of drugs containing: amphetamine (amphetamine and methamphetamine), (MDMA and MDEA, MDA), , opium (codeine, morphine ,6-acetylmorphine), cannabis metabolites THCA, Ketamine, Norketamine, methadone and BZD drug (containing diazepam, nimetazepam nordiazepam, temazepam, oxazepam, triazolam, flunitrazepam, nitrazepam, alprazolam, lorzepam). |
