中山醫學大學機構典藏 CSMUIR:Item 310902500/4040
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    题名: Silibinin 抑制不同腎臟癌細胞株(Caki-1, Caki-2, 786- 0)轉移及侵襲之機制探討
    Silibinin Inhibits the Invasion and Migration of Renal Cell Carcinoma Cells in Vitro and in Vivo and Enhances the Cytotoxic Effects of Anti-cancer Agents
    作者: 張浤榮;謝易修
    贡献者: 中山醫學大學：醫學研究所
    日期: 2011
    上传时间: 2011-07-01T04:38:48Z (UTC)
    摘要: Cancer metastasis, involving multiple processes and various cytophysiological changes,
    is a primary cause of cancer death and may complicate the clinical management, even lead to
    death. Silibinin is a flavonoid antioxidant and wildly used for its antihepatotoxic properties
    and recent studies have revealed pleiotropic anticancer and antiproliferative capabilities of
    silibinin. In this study, we first observed that silibinin exerted a dose-dependent inhibitory
    effect on the invasion and motility of 786-O renal cell carcinoma cells in the absence of
    cytotoxicity. To look at the precise involvement of silibinin in cancer metastasis, 786-O cells
    were treated with silibinin at various concentrations, up to 50 μM, for a defined period and
    then subjected to gelatin zymography, casein zymography and western blot to investigate the
    impacts of silibinin on metalloproteinase-2, -9, urokinase plasminogen activator (u-PA), and
    MAPK pathway signaling protein, respectively. The results showed that silibinin treatment
    decreased the expressions of MMP-2 and u-PA in a concentration-dependent manner and
    decrease the expression of p-p38 and p-Erk1/2. Thus, silibinin may possess an anti-metastatic
    activity in 786-O renal cell carcinoma cells. To further evaluate the anti-tumor effect of
    silibinin, an in vivo anti-tumor study using nude mice xenograft model by a subcutaneous
    inoculation of RCC 786-O cells was performed. Small solid tumors was observed on 8 days
    following cell inoculation and a 70.1% reduction of tumor volume by silibinin feeding was
    seen on day 44, compared to control animals.
    URI: https://ir.csmu.edu.tw:8080/ir/handle/310902500/4040
    显示于类别:[醫學研究所] 研究計劃

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