Assessing the exacerbations risk of influenza-associated chronic occupational asthma

doi:10.1111/j.1539-6924.2010.01402.x

中山醫學大學機構典藏 CSMUIR > 健康管理學院 > 公共衛生學系暨碩士班 > 期刊論文 > Item 310902500/3844

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题名:	Assessing the exacerbations risk of influenza-associated chronic occupational asthma
作者:	Chung-Min Liao;Nan-Hung Hsieh;Chia-Pin Chio;Szu-Chieh Chen
贡献者:	中山醫學大學:公共衛生學系
关键词:	detrended fluctuation analysis;exacerbations risk;influenza;probabilistic risk assessment
日期:	2010
上传时间:	2011-06-15T04:10:41Z (UTC)
ISSN:	0272-4332
摘要:	The purpose of this article was to conduct a risk-based study based on a linkage of experimental human influenza infections and fluctuation analysis of airway function to assess whether influenza viral infection was risk factor for exacerbations of chronic occupational asthma. Here we provided a comprehensive probabilistic analysis aimed at quantifying influenza-associated exacerbations risk for occupational asthmatics, based on a combination of published distributions of viral shedding and symptoms scores and lung respiratory system properties characterized by long-range peak expiratory flow (PEF) dynamics. Using a coupled detrended fluctuation analysis-experimental human influenza approach, we estimated the conditional probability of moderate or severe lung airway obstruction and hence the exacerbations risk of influenza-associated occupational asthma in individuals. The long-range correlation exponent ( alpha ) was used as a predictor of future exacerbations risk of influenza-associated asthma. For our illustrative distribution of PEF fluctuations and influenza-induced asthma exacerbations risk relations, we found that the probability of exacerbations risk can be limited to below 50% by keeping alpha to below 0.53. This study also found that limiting wheeze scores to 0.56 yields a 75% probability of influenza-associated asthma exacerbations risk and a limit of 0.34 yields a 50% probability that may give a representative estimate of the distribution of chronic respiratory system properties. This study implicates that influenza viral infection is an important risk factor for exacerbations of chronic occupational asthma.
URI:	https://ir.csmu.edu.tw:8080/ir/handle/310902500/3844 http://dx.doi.org/10.1111/j.1539-6924.2010.01402.x
關聯:	Risk Analysis: An International Journal; Jul2010, Vol. 30 Issue 7, p1062-1075
显示于类别:	[公共衛生學系暨碩士班] 期刊論文

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