中山醫學大學機構典藏 CSMUIR:Item 310902500/3739
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    题名: Beneficial effects of treatment with cystamine on brain in NZB/W F1 mice
    作者: Tsai-Ching Hsu;Yi-Chen Chen;Wen-Xian Lai;Szu-Yi Chiang;Chih-Yang Huang;Bor-Show Tzang
    贡献者: 中山醫學大學:醫學系生化科
    关键词: NP-SLE (Neuropsychiatric SLE);MMP-9 (Matrix metalloproteinase-9);uPA (Urokinase-type plasminogen activator);Apoptosis;NF-κB
    日期: 2006
    上传时间: 2011-05-11T07:20:52Z (UTC)
    ISSN: 0014-2999
    摘要: The involvement of the central nervous system (CNS) or neuropsychosis has been reported in patients with systemic lupus erythematosus (SLE) and considered a major cause of long-standing functional impairment and mortality. However, little is known in the improvement of the brain abnormality in SLE. To investigate the effect and mechanism of cystamine on brain in SLE, NZB/W F1 mice were used as the animal model. Gel zymography, caspase-3 activity assay and Western blots were performed to elucidate the effect of cystamine. Significant reduction of matrix metalloproteinases (MMP)-9/MMP-2 ratio and urokinase-type plasminogen activator (uPA) expression was detected in brain of NZB/W F1 mice treated with cystamine as compared to control group. Significant increase of heat-shock protein (HSP)-70 and HSP27 was detected in brain of NZB/W F1 mice treated with cystamine as compared to control group. Additionally, significant reduction of mitochondrial dependent apoptosis was observed in brain of NZB/W F1 mice treated with cystamine as compared to control group by increasing BCL-2 and reducing caspase-9, Bad, and Apaf-1 expression. Moreover, increased phosphorylated p65 (NF-κB) protein was observed in brain of NZB/W F1 mice treated with cystamine as compared to control group. These experimental results firstly demonstrated the beneficial effects of cystamine on brain in NZB/W F1 mice and suggested the therapeutic potential in patients with neuropsychiatric SLE (NP-SLE).
    URI: https://ir.csmu.edu.tw:8080/handle/310902500/3739
    http://dx.doi.org/10.1016/j.ejphar.2008.06.078
    關聯: European Journal of Pharmacology,Volume 591, Issues 1-3, 4 September 2008, Pages 307-314
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