亞硝基梅納反應物致癌作用之研究(I)

中山醫學大學機構典藏 CSMUIR > 醫學院 > 生化微生物免疫研究所 > 研究計劃 > Item 310902500/3238

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题名:	亞硝基梅納反應物致癌作用之研究(I) Carcinogenicity Studies on N-nitrosated Products of the Maillard Browning Reaction
作者:	王朝鐘;曾翠華;黃惠珮 Wang, Chau-Jong;Tseng, Tsui-Hwa;Huang, Hui-Pei
贡献者:	中山醫學院生化學科
关键词:	梅納反應產物;基因毒性;致癌基因活化;致癌機轉 Maillard reaction product;Genotoxicity;Oncogene activation;Carcinogenesis
日期:	1993
上传时间:	2010-12-16T03:47:39Z (UTC)
摘要:	2-Acetylpyrrole (AP) is a product of model browning system. Reaction of AP with nitrite gives two N-nitropyrroles. Spectral studies including ultraviolet (UV), mass (MS), nuclear magnetic resonance (NMR), infred (IR) and elemental analysis (EA) has suggested the chemical structures of the compounds as 1-nitro-2-acetylpyrrole (NAP) and 1,3,5-trinitro-2-acetylpyrrole (TNAP). NAP and TNAP are modulately mutagenic to the Salmonella TA98 and TA100 in absence of mammalian activation system and are remarkably cytotoxic to mouse C3H10T1/2 cells. These results suggest that the formation of direct-acting mutagens of nitro-derivatives in nitrite-containing food or formed in vivo by nitrosation following ingestion of AP.
URI:	https://ir.csmu.edu.tw:8080/handle/310902500/3238
显示于类别:	[生化微生物免疫研究所] 研究計劃

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