為探討Colorectal cancer是如何形成的,本實驗室和成功大學醫學院呂增宏老師、李政昌醫師合作,分析了56位大腸癌患者其正常及癌症的檢體。我們發現大腸癌檢體FAK及c-Src過量表達的比率分別是89.5%及94.64%,且兩者在Colon cancer的增加似乎有同步的傾向。而另外我們也在81% colon cancer中發現了Cortactin的過量表達。
In order to investigate the tumorigeneic mechanisms of colon cancer, we collaborated with Drs. Lee, J.-C., and Leu, T.-H. to analyze 56 paired cancer-normal mucosa specimens from colorectal cancer patients. Compared to normal mucosa, enhanced FAK and c-Src expression in tumor specimens (T/N>1) was observed in 89.5% and 94.64% tumor samples respectively. Interestingly, we observed paralleled enhancement of protein expression of both nonreceptor tyrosine kinases in colorectal cancer. Furthermore, enhanced cortactin overexpression was also detected in 81% colon tumor specimens.
