肥胖症心臟凋亡途徑與治療的探討---肥胖症心臟Type I 和 Type II的凋亡; ACE inhibitor治療對肥胖心臟凋亡的保護;運動治療對肥胖心臟凋亡的改善(I)

中山醫學大學機構典藏 CSMUIR > 醫學科技學院 > 物理治療學系暨碩士班 > 研究計劃 > Item 310902500/2945

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题名:	肥胖症心臟凋亡途徑與治療的探討---肥胖症心臟Type I 和 Type II的凋亡;ACE inhibitor治療對肥胖心臟凋亡的保護;運動治療對肥胖心臟凋亡的改善(I) Cardiac Apoptosis and Treatments in Obesity---Type I and II Apoptosis in Obesity;Cardiac Protection of ACE Inhibitor in Obesity;Effect of Exercise on Cardiac Apoptosis in Obesity (I)
作者:	李信達;黃志揚 Lee, Hsin-Ta;Huang, Chih-Yang
贡献者:	中山醫學大學物理治療學系
关键词:	Heart;Fas receptor-dependent pathway;Bcl2 family;Cytochrome c;Caspase
日期:	2006
上传时间:	2010-11-29T04:49:06Z (UTC)
摘要:	Background. Obesity is often associated with the development of heart failure but the precise mechanisms remain uncertain. The purpose of this study was to evaluate the key components of Fas receptor-dependent apoptotic pathway in excised hearts from obese Zucker rats. Methods. Twelve obese Zucker rats were studied at 5~6 months of age and twelve age-matched lean Zucker rats served as control. The myocardial architecture, key components of Fas receptor-dependent apoptotic pathway, apoptotic activity, and fibrosis in the excised left ventricle from rats were measured by Hematoxylin-eosin staining, Western blotting, RT-PCR, TUNEL assay and Masson trichrome staining. Results. The ratios of whole heart weight to tibia length were significantly increased in the obese group. Cardiomyocyte disarray, increased interstitial space, TUNEL-positive cardiac myocytes and minor cardiac fibrosis were observed in obese rat hearts. The Fas ligand, Fas death receptors, and FADD were all significantly increased in obese rat hearts. In addition, pro-caspase-8 and pro-caspase-3 were significantly decreased whereas activated caspase-8 and activated caspase-3 were significantly increased in obese rat hearts, compared with lean rat heart, imply pro-forms of caspase-8 and caspase-3 were cleaved into active-forms caspase-8 and caspase-3. Conclusions. The cardiac Fas receptor-dependent apoptotic pathways were more activated in obese rat hearts, which may provide one of possible apoptotic mechanism for developing heart failure in obesity.
URI:	https://ir.csmu.edu.tw:8080/handle/310902500/2945
显示于类别:	[物理治療學系暨碩士班] 研究計劃

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