| Abstract: | 本實驗探討維生素E與魚油對於降血壓方面是否有加成作用,。六組高血壓老鼠分別餵食Semipurified的飲食八個星期,每組有十一隻老鼠,飲食中含有玉米油及魚油兩種油脂,另外每種油脂又含有50,5000,或15000ppm維生素E。動物體內油脂狀況利用氣相層析儀分析血漿中脂肪酸成分來證實,血漿中維生素E利用高效能液相層析儀來分析,老鼠餵食不同劑量維生素E其血漿中維生素E濃度有顯著的差異(p<0.05)。與餵食玉米油比較,餵食魚油顯著的降低血漿中維生素E濃度(p<0.05),利用量尾壓的方法,不管是收縮壓,平均血壓或是舒張壓,餵食玉米油的老鼠顯然高於餵食魚油的老鼠(p<0.05)。然而維生素E對血壓調控並無影響。血漿中Thromboxane,利用放射免疫分析法來測量,玉米油組顯然高於魚油組(p<0.05),與50ppm維生素E比較,5000ppm和15000ppm維生素E顯然降低血漿中Thromboxane濃度(p<0.05),根據以前報告,Thromboxane可以藉由它血管收縮的作用來調控血壓,另外維生素E可以影響Thomboxane合成,但本實驗結果卻證實維生素E並不會藉由影響Thromboxane合成來達到調控血壓的目的。
Whether the alterations in the synthesis of thromboxane A/sub 2/ is the direct mechanism underlying the blood pressure-lowering effect of fish oil was investigated in this study. Six groups of 11 male spontaneously hypertensive rats were fed semipurified diets containing corn or fish oils and graded levels (50, 5000 or 15000ppm) of dietary vitamin E for 8 weeks. Plasma thromboxane A/sub 2/, assayed by RIA, was significantly greater in the corn oil group than in the fish oil group (p<0.05). Compared to 50ppm dietary vitamin E, 5000 and 15000ppm dietary vitamin E, respectively, significantly decreased plasma thromboxane A/sub 2/ (p<0.05). Systolic, mean or diastolic blood pressure, evaluated by the tail cuff method, were significantly higher in the corn oil group than in the fish oil group (p<0.05). However, vitamin E had no effect on blood pressure. No relationship between thromboxane A/sub 2/and blood pressure was found. Experimental results indicated the alterations in the synthesis of thromboxane A/sub 2/were not the direct antihypertensive effect of fish oil. |
