中山醫學大學機構典藏 CSMUIR:Item 310902500/2535
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    题名: 蛋白激酵素C可能沒有參與假孕鼠子宮蛻膜之誘發
    Protein Kinase C May Not Involved in the Initiation of Decidualization at Pseudopregnant Rats
    作者: 徐志誠;蔡仁祥;謝易修;黃志揚;張振隆;蔡金秋;劉惠珍;楊連泉;林隆堯;鍾緯儒;劉哲育
    Jyh-Cherng Shyu;Jen-Hsiang Tsai;Yiu-shou Hsieh;Chih-Yang Huang;Chen-Lurng Chang;Chin-Chiu Tsai;Hui-Chen Liu;Lien-Chuan Yang;Long-Yau Lin;Wei-Ju Chung;Jer-Yuh Liu
    贡献者: 中山醫學大學
    关键词: 蛋白激酵素C;子宮蛻膜形成;抗組織胺藥物
    protein kinase C;decidualization;diphenhydramine
    日期: 2002-01-01
    上传时间: 2010-10-26T06:59:45Z (UTC)
    出版者: 教務處出版組
    摘要: 先前之研究發現假孕鼠與真懷孕屬之子宮蛻膜形成與蛋白激酵素C異構體之表現有關，然而組織胺 ( Histamine ) 對蛋白激酵素之影響至今尚未清楚。本篇實驗乃應用抗組織胺藥物 ( Diphenhydramine ) 對於假孕鼠子宮蛻膜形成時蛋白激酵素C異構體之表現加以觀察。大白鼠施予刮劃刺激誘導後應用抗組織胺藥物注射，結果發現抗組織胺藥物組子宮蛻膜形成被抑制，蛋白激酵素C異構體α和ζ表現在蛻膜細胞質與微粒部分含量都降低。若同時給予蛋白激酵素C抑制劑 ( Staurosporine, H7 ) 之處理，結果發現Diphenhydramine和TPA抑制子宮蛻膜形成有被抑制的現象，而其他抗蛻膜形成相關之藥物諸如Promethazine 、Epinephrine等就無法恢復。另外單獨應用Staurosporine處理，不影響子宮蛻膜之形成。綜合以上結果，推論蛋白激酵素C可能不需要參與假孕鼠子宮蛻膜形成初期之誘發。
    Protein kinase C (PKC) isoforms have previously been found to be associated with the modulation of decidualization in pseudopregnant and pregnant rats. This study further investigates the effect of diphenhydramine on the expressions of PKC isoforms during trauma-stimulated decidualization. After trauma- stimulated, decidualization was inhibited by co-treatment with 1 mg diphenhydramine per rat. Levels of PKC α and PKCζ proteins were down-modulated at hour 4 and 8, then returned to base level at hour 72. Moreover, pretreatment with the PKC inhibitors staurosporine and H7 blocked the inhibitory effect of diphenhydramine or 12-o-tetrodecanoyl-phobol-acetate (TPA). The inhibitory effect of other anti-decidualization agents, however, was not reversed by staurosporine. When pretreated with staurosporine only, decidualization was not influence. Therefore, we suggested that PKCs may be uninvolved in the initiation decidualization in pseudopregnant rats.
    URI: https://ir.csmu.edu.tw:8080/handle/310902500/2535
    關聯: 中山醫學雜誌 v13 n.1 p25-33
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