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https://ir.csmu.edu.tw:8080/ir/handle/310902500/24918
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| 题名: | Bioactive peptides attenuate cardiac apoptosis in spontaneously hypertensive rat hearts through activation of autophagy and mitochondrial biogenesis pathway |
| 作者: | Lin, WT;Nithiyanantham, S;Hsieh, DJY;Chen, RJ;Day, CH;Liao, JY;Kuo, CH;Mahalakshmi, B;Kuo, WW;Huang, CY |
| 关键词: | apoptosis;autophagy;bioactive peptides;mitochondrial biogenesis;SHR |
| 日期: | 2020 |
| 上传时间: | 2022-08-09T08:10:08Z (UTC)
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| 出版者: | WILEY |
| ISSN: | 1520-4081 |
| 摘要: | Alcalase potato protein hydrolysate (APPH) might have a very important role in therapeutic effects. This study aims to examine the beneficial effects of bioactive peptides (DIKTNKPVIF [DI] and IF) from APPH supplement in the regulation of cardiac apoptosis, autophagy, and mitochondrial biogenesis pathway in spontaneously hypertensive rats (SHR). We have investigated ejection fraction, fractional shortening, Tunel assay, apoptosis, autophagy, and mitochondrial biogenesis pathway marker expression to show the efficacy of bioactive peptides in an SHR model. Bioactive peptides significantly upregulate ejection fraction and fractional shortening in SHR rats. SHR rats exhibited higher protein expression of apoptotic markers such as BAD, cytochromec, and caspase 3. Finally, the bioactive peptides upregulate survival proteins (p-AKT/p-PI3K), autophagy (Beclin1/LC3B), and mitochondrial biogenesis (p-AMPK alpha/SIRT1/PGC1 alpha/p-Foxo3a/Nrf2/CREB) marker expressions compared with the SHR groups. In summary, the bioactive peptides protect the heart tissues through the activation of autophagy and mitochondrial biogenesis pathway and thereby attenuate cardiac apoptosis in a spontaneously hypertensive rat model. |
| URI: | http://dx.doi.org/10.1002/tox.22916
https://www.webofscience.com/wos/woscc/full-record/WOS:000539436200009
https://ir.csmu.edu.tw:8080/handle/310902500/24918 |
| 關聯: | ENVIRONMENTAL TOXICOLOGY ,2020 ,v35 ,issue 7 ,p804-810 |
| 显示于类别: | [中山醫學大學研究成果] 期刊論文
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