Accelerated Muscle Recovery After In Vivo Curcumin Supplementation

doi:10.1177/1934578X20901898

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/24901

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/24901

Title:	Accelerated Muscle Recovery After In Vivo Curcumin Supplementation
Authors:	Tsai, SW;Huang, CC;Hsu, YJ;Chen, CJ;Lee, PY;Huang, YH;Lee, MC;Chiu, YS;Tung, YT
Keywords:	curcumin;contusion;mass-drop injury;diclofenac
Date:	2020
Issue Date:	2022-08-09T08:09:50Z (UTC)
Publisher:	SAGE PUBLICATIONS INC
ISSN:	1934-578X
Abstract:	The currently available treatment options for muscle injuries are suboptimal and often delay muscle recovery. In this study, the effects of curcumin on inflammation and skeletal muscle regeneration after contusion-induced injury in mice were investigated. The mice were randomly assigned to 4 groups, namely normal control (NC), with induced injury (mass-drop injury, MDI) and without treatment (MDI [M]), with induced injury and diclofenac (DCF) treatment (MDI + DCF [M + D]), and with induced injury and curcumin treatment (MDI + curcumin [M + C]). Contusion-induced injury was inflicted on the left gastrocnemius muscle, and DCF or curcumin was orally administered after injury once per day for 7 days. The M group exhibited significantly higher lipid peroxidation, myeloperoxidase (MPO), and desmin than the NC group. The M + D and M + C groups have lower lipid peroxidation and neutrophils (decrease in MPO protein) and higher muscle satellite cell regeneration (increase in desmin protein) than the M group. Additionally, for the contusion-induced muscle injury, curcumin could affect the specific proteins of inflammation, neutrophils, and differentiation of satellite cells, including Ikk-alpha/beta, MPO, and myogenin. In conclusion, curcumin potentially accelerates muscle recovery; therefore, it may be a potential candidate for further research as an effective treatment to enhance muscle repair.
URI:	http://dx.doi.org/10.1177/1934578X20901898 https://www.webofscience.com/wos/woscc/full-record/WOS:000508587500001 https://ir.csmu.edu.tw:8080/handle/310902500/24901
Relation:	NATURAL PRODUCT COMMUNICATIONS ,2020 ,v15 ,issue 1
Appears in Collections:	[中山醫學大學研究成果] 期刊論文

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