Heat-Killed Lactobacillus reuteri GMNL-263 Inhibits Systemic Lupus Erythematosus-Induced Cardiomyopathy in NZB/W F1 Mice

doi:10.1007/s12602-020-09668-1

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/24892

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/24892

Title:	Heat-Killed Lactobacillus reuteri GMNL-263 Inhibits Systemic Lupus Erythematosus-Induced Cardiomyopathy in NZB/W F1 Mice
Authors:	Yeh, YL;Lu, MC;Tsai, BCK;Tzang, BS;Cheng, SM;Zhang, XY;Yang, LY;Mahalakshmi, B;Kuo, WW;Xiang, P;Huang, CY
Keywords:	Systemic lupus erythematosus;Atherosclerosis;Cardiomyopathy;Probiotic bacteria;Lactobacillus reuteri GMNL-263
Date:	2021
Issue Date:	2022-08-09T08:09:41Z (UTC)
Publisher:	SPRINGER
ISSN:	1867-1306
Abstract:	It has been increasingly recognized that accelerated atherosclerosis is a major cause of morbidity and mortality in patients with systemic lupus erythematosus, a multisystem autoimmune disease. In this study, we investigated the anti-apoptotic effects of heat-killed Lactobacillus reuteri GMNL-263 on the cardiac tissue of NZB/W F1 mice. The myocardial architecture of the mice heart was observed and evaluated using different staining techniques such as hematoxylin and eosin, TUNEL assay, Masson's trichrome, and fluorescent immunohistochemistry. Additionally, the probiotics-related pathway proteins were analyzed via western blot analysis. Our results showed prevention of enlarged interstitial spaces and abnormal myocardial structures in the hearts of NZB/W F1 mice with L. reuteri GMNL-263 feeding. Significant reduction in TUNEL-positive cells, Fas death receptor-related components, and apoptosis was also detected in the cardiac tissues of the NZB/W F1 mice after L. reuteri GMNL-263 feeding compared with the control group. These findings are the first to reveal the protective effects of L. reuteri GMNL-263 against cardiac abnormalities in NZB/W F1 mice and suggest the potential clinical applications of L. reuteri GMNL-263 in the treatment of SLE-related cardiovascular diseases.
URI:	http://dx.doi.org/10.1007/s12602-020-09668-1 https://www.webofscience.com/wos/woscc/full-record/WOS:000538978400001 https://ir.csmu.edu.tw:8080/handle/310902500/24892
Relation:	PROBIOTICS AND ANTIMICROBIAL PROTEINS ,2021 ,v13 ,issue 1 ,p51-59
Appears in Collections:	[中山醫學大學研究成果] 期刊論文

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