Involvement of FGFR4 Gene Variants on the Clinicopathological Severity in Urothelial Cell Carcinoma

doi:10.3390/ijerph17010129

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/24885

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/24885

Title:	Involvement of FGFR4 Gene Variants on the Clinicopathological Severity in Urothelial Cell Carcinoma
Authors:	Tsay, MD;Hsieh, MJ;Lee, CY;Wang, SS;Chen, CS;Hung, SC;Lin, CY;Yang, SF
Keywords:	fibroblast growth factor receptor 4;single-nucleotide polymorphism;urothelial cell carcinoma;tumor stage
Date:	2020
Issue Date:	2022-08-09T08:09:35Z (UTC)
Publisher:	MDPI
ISSN:	1661-7827
Abstract:	Fibroblast growth factor receptor 4 (FGFR4) plays a prominent role in cell proliferation and cancer progression. This study explored the effect of FGFR4 single-nucleotide polymorphisms (SNPs) on the clinicopathological characteristics of urothelial cell carcinoma (UCC). This study was conducted to survey the possible correlation of the polymorphism of FGFR4 to the risk and clinicopathologic characteristics of UCC. Four loci of FGFR4 (rs2011077 T > C, rs351855 G > A, rs7708357 G>A, and rs1966265 A > G) were genotyped via the TaqMan allelic discrimination approach in 428 UCC cases and 856 controls. The results indicated that UCC subjects who carried the SNP rs2011077 TC+CC genotypes were significantly related to a higher tumor stage (odds ratio (OR): 1.751, 95% confidence interval (CI): 1.078-2.846), primary tumor size (OR: 1.637, 95% CI: 1.006-2.662), and histopathologic grading (OR: 1.919, 95% CI: 1.049-3.511). Moreover, the SNP rs1966265 AG+GG genotypes were prominently related to a higher tumor stage (OR: 1.769, 95% CI: 1.082-2.891), primary tumor size (OR: 1.654, 95% CI: 1.011-2.706), and histopathologic grading (OR: 2.006, 95% CI: 1.096-3.674) compared to individuals with AA homozygotes. In conclusion, our data reveal association of FGFR4 polymorphisms with UCC clinicopathologic characteristics. FGFR4 polymorphisms may serve as a marker or therapeutic target in UCC development.
URI:	http://dx.doi.org/10.3390/ijerph17010129 https://www.webofscience.com/wos/woscc/full-record/WOS:000509391500129 https://ir.csmu.edu.tw:8080/handle/310902500/24885
Relation:	INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH ,2020 ,v17 ,issue 1
Appears in Collections:	[中山醫學大學研究成果] 期刊論文

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