ALK variants, PD-L1 expression, and their association with outcomes in ALK-positive NSCLC patients

doi:10.1038/s41598-020-78152-1

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/24855

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/24855

Title:	ALK variants, PD-L1 expression, and their association with outcomes in ALK-positive NSCLC patients
Authors:	Chang, GC;Yang, TY;Chen, KC;Hsu, KH;Huang, YH;Su, KY;Yu, SL;Tseng, JS
Date:	2020
Issue Date:	2022-08-09T08:09:05Z (UTC)
Publisher:	NATURE RESEARCH
ISSN:	2045-2322
Abstract:	It remains unclear how programmed death-ligand 1 ( PD-L1) expression interacts with anaplastic lymphoma kinase (ALK) mutation, its variants, and the outcome of treatment. One hundred and twenty four out of 1255 patients (9.9%) were deemed ALK-positive by the Ventana IHC assay. PD-L1 status and ALK variants were available in 100 and 59 patients, respectively. PD-L1 positive (TPS >= 1%) and strong positive (TPS >= 50%) rate was 50% and 16%, respectively. A total of 64 variant types were detected in 59 patients. V1 ( 32.8%) and V3a/b (28.1%) were the most common variants. There was no significant association between ALK variants and the PD-L1 expression. The presence of V3a/b subtype independently predicted a worse overall survival in patients receiving ALK inhibitor(s) (aHR 5.10 [95% CI 1.22-21.25], P = 0.025) and platinum plus pemetrexed (aHR 9.62 [95% CI 1.90-48.80], P = 0.006). While incorporating ALK variants and PD-L1 expression together, patients with non-V3a/b/positive PD-L1 showed a trend towards longer OS. In conclusion, ALK-positive NSCLC patients possess a high PD-L1 expression rate. Although there was no significant association between PD-L1 expression and ALK variants, the outcome of ALK- positive patients could be sorted by these two biomarkers.
URI:	http://dx.doi.org/10.1038/s41598-020-78152-1 https://www.webofscience.com/wos/woscc/full-record/WOS:000615394300063 https://ir.csmu.edu.tw:8080/handle/310902500/24855
Relation:	SCIENTIFIC REPORTS ,2020 ,v10 ,issue 1
Appears in Collections:	[中山醫學大學研究成果] 期刊論文

Files in This Item:

File	Description	Size	Format
index.html		0Kb	HTML	265	View/Open

Loading...