Incidence and risk of sepsis following appendectomy: a nationwide population-based cohort study

doi:10.1038/s41598-020-66943-5

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/24844

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/24844

Title:	Incidence and risk of sepsis following appendectomy: a nationwide population-based cohort study
Authors:	Wu, MC;Tsou, HK;Lin, CL;Wei, JCC
Date:	2020
Issue Date:	2022-08-09T08:08:54Z (UTC)
Publisher:	NATURE RESEARCH
ISSN:	2045-2322
Abstract:	Appendectomy is a frequently performed surgical procedure; however, long-term consequences have not been fully explored. We used a nationwide population-based cohort to determine whether patients undergoing appendectomy are at an increased risk of sepsis. Overall, 252,688 patients undergoing appendectomy and 252,472 matched controls were identified from the National Health Insurance Research Database in Taiwan. A propensity score analysis was used for matching age, sex, index year and comorbidities at a ratio of 1:1. Multiple Cox regression and stratified analyses were used to estimate the adjusted hazard ratio (aHR) of developing sepsis. Patients undergoing appendectomy had a 1.29 times (aHR: 1.29; 95% confidence interval [CI], 1.26-1.33) higher risk of developing sepsis than those not undergoing. Patients aged 20-49 years had a 1.58-fold higher risk of sepsis in the appendectomy cohort (aHR; 95% CI, 1.50-1.68). Also, having undergone appendectomy, patients had a higher likelihood of sepsis, regardless of sex and with or without comorbidities. Patients with <1 year follow-up showed a 1.98-fold risk of sepsis in the appendectomy cohort. Patients with 1-4 and >= 5 years follow-up showed a 1.29 and 1.11-fold risk of sepsis, respectively. Future research is required to elucidate the possible immuno-pathological mechanisms of these associations.
URI:	http://dx.doi.org/10.1038/s41598-020-66943-5 https://www.webofscience.com/wos/woscc/full-record/WOS:000543994900008 https://ir.csmu.edu.tw:8080/handle/310902500/24844
Relation:	SCIENTIFIC REPORTS ,2020 ,v10 ,issue 1
Appears in Collections:	[中山醫學大學研究成果] 期刊論文

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