Differential associations of proinflammatory and anti-inflammatory cytokines with depression severity from noncancer status to breast cancer course and subsequent chemotherapy

doi:10.1186/s12885-020-07181-w

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/24840

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/24840

Title:	Differential associations of proinflammatory and anti-inflammatory cytokines with depression severity from noncancer status to breast cancer course and subsequent chemotherapy
Authors:	Tzang, BS;Chen, VCH;Hsieh, CC;Wang, WK;Weng, YP;Ho, HY;Hsu, YT;Hsaio, HP;Weng, JC;Chen, YL
Keywords:	Cytokines;Depression;Breast cancer;Chemotherapy;Moderation
Date:	2020
Issue Date:	2022-08-09T08:08:51Z (UTC)
Publisher:	BMC
Abstract:	BackgroundIn this study, we examined the differential associations of various proinflammatory and anti-inflammatory cytokines with depression severity from the development of breast cancer to subsequent chemotherapy treatment.MethodsA cross-sectional study was conducted on a sample of 116 women: 29 controls without cancer, 55 patients with breast cancer who were not receiving chemotherapy, and 32 patients with breast cancer who were receiving chemotherapy. Blood samples were assayed to evaluate serum levels of the following cytokines: interferon-gamma, interleukin (IL)-12 (p70), IL-1 beta, IL-2, tumor necrosis factor (TNF)-alpha, IL-4, IL-5, IL-10, IL-13, IL-6, and IL-17A. Depression severity was assessed using the Patient Health Questionnaire.ResultsAfter adjustment for sociodemographics, consistent patterns of the association between cytokine and depression were noted in the different groups. No significant associations were observed in the controls. Inverse associations were observed between cytokines levels and depression severity in patients with breast cancer who were not receiving chemotherapy, whereas positive associations were noted in patients with breast cancer who were receiving chemotherapy. Specific differential relationships between IL-5 levels and depression severity were found between patients with breast cancer who were receiving and not receiving chemotherapy.ConclusionsOur study revealed differential relationships between cytokine levels and depression severity with the development of cancer. Immunostimulation and immunosuppression in breast cancer and cancer treatment may account for the differential responses with the development of breast cancer.
URI:	http://dx.doi.org/10.1186/s12885-020-07181-w https://www.webofscience.com/wos/woscc/full-record/WOS:000555875200002 https://ir.csmu.edu.tw:8080/handle/310902500/24840
Relation:	BMC CANCER ,2020 ,v20 ,issue 1
Appears in Collections:	[中山醫學大學研究成果] 期刊論文

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