Risk of Total Knee and Hip Arthroplasty in Patients With Rheumatoid Arthritis: A 12-Year Retrospective Cohort Study of 65,898 Patients

doi:10.1016/j.arth.2020.06.085

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/24790

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/24790

Title:	Risk of Total Knee and Hip Arthroplasty in Patients With Rheumatoid Arthritis: A 12-Year Retrospective Cohort Study of 65,898 Patients
Authors:	Lee, YH;Ko, PY;Kao, SL;Lin, MC;Wei, JCC
Keywords:	rheumatoid arthritis;total knee arthroplasty;total hip arthroplasty;population-based cohort study;risk;big data
Date:	2020
Issue Date:	2022-08-09T08:08:02Z (UTC)
Publisher:	CHURCHILL LIVINGSTONE INC MEDICAL PUBLISHERS
ISSN:	0883-5403
Abstract:	Background: Rheumatoid arthritis (RA) is an inflammatory disease that causes the destruction of soft tissues and cartilage around joints. Owing to the widespread use of potent disease-modifying antirheumatic drugs, the need for total knee and hip arthroplasties (TKA and THA) has been reduced in patients with RA. However, the current association between RA and either THA or TKA has not been demonstrated in large-scale epidemiological studies. Methods: We conducted a large-scale retrospective cohort study of patients diagnosed with RA during a 12-year period (2000-2012) in Taiwan. We recruited 32,949 patients with RA and 32,949 individually propensity score-matched non-RA controls. Results: After adjusting for confounding factors, we found that the risk of THA or TKA was 4.02 times higher in patients with RA than in those without RA (95% confidence interval [CI], 3.77-4.52). The risk of THA or TKA was highest in patients with RA younger than 40 years (adjusted hazard ratio, 43.18; 95% CI, 16.01-116.47). Compared with non-RA patients, patients with RA were 4.82 times more likely to undergo THA (95% CI, 3.84-6.04), 3.85 times more likely to undergo TKA (95% CI, 3.48-4.25), and 19.06 times more likely to undergo both THA and TKA (95% CI, 8.90-40.80). Conclusion: These findings document a 4.02-fold greater long-term risk of undergoing THA or TKA in RA patients relative to non-RA patients in Taiwan. (C) 2020 Elsevier Inc. All rights reserved.
URI:	http://dx.doi.org/10.1016/j.arth.2020.06.085 https://www.webofscience.com/wos/woscc/full-record/WOS:000589425600014 https://ir.csmu.edu.tw:8080/handle/310902500/24790
Relation:	JOURNAL OF ARTHROPLASTY ,2020 ,v35 ,issue 12 ,p3517-3523
Appears in Collections:	[中山醫學大學研究成果] 期刊論文

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