Influence of skin melanisation and ultraviolet radiation on biomarkers of systemic oxidative stress

doi:10.1016/j.freeradbiomed.2020.07.034

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/24675

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/24675

Title:	Influence of skin melanisation and ultraviolet radiation on biomarkers of systemic oxidative stress
Authors:	Shih, BB;Farrar, MD;Vail, A;Allan, D;Chao, MR;Hu, CW;Jones, GDD;Cooke, MS;Rhodes, LE
Keywords:	Oxidative stress;Melanin;Skin;Ultraviolet radiation;Nucleic acids;Biomarkers
Date:	2020
Issue Date:	2022-08-09T08:06:11Z (UTC)
Publisher:	ELSEVIER SCIENCE INC
ISSN:	0891-5849
Abstract:	Skin melanisation ranges widely across human populations. Melanin has antioxidant properties and also acts as a filter to solar ultraviolet radiation (UVR) incident upon the skin. In this study we firstly examined whether melanin level might influence baseline levels of systemic oxidative stress, in 65 humans in vivo from the same geographical area ranging from the lightest to darkest skin type (phototype I-VI). This was examined in wintertime (latitude 53.5 degrees N). Remarkably, we found that urinary biomarkers of oxidatively-generated DNA damage (8-oxodG) and RNA damage (8-oxoGuo) were significantly correlated with skin lightness (L*), such that 14-15% of the variation in their baseline levels could be explained by skin colour. Next we exposed 15 humans at the extremes of skin melanisation to a simulated summer-time exposure of solar UVR (95% UVA, 5% UVB; dose standardised to sunburn threshold), following which they provided a sample of every urine void over the next five days. We found that UVR induced a small but significant increase in urinary 8-oxodG and 8-oxoGuo, with differing kinetics between skin types. Thus greater melanisation is associated with protection against systemic oxidative stress, which may reflect melanin's antioxidant properties, and solar UVR exposure also influences systemic oxidative stress levels in humans. These novel findings may have profound implications for human physiology and health.
URI:	http://dx.doi.org/10.1016/j.freeradbiomed.2020.07.034 https://www.webofscience.com/wos/woscc/full-record/WOS:000595854700005 https://ir.csmu.edu.tw:8080/handle/310902500/24675
Relation:	FREE RADICAL BIOLOGY AND MEDICINE ,2020 ,v160 ,p40-46
Appears in Collections:	[中山醫學大學研究成果] 期刊論文

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