Chronic rhinosinusitis after radiotherapy in patients with head and neck cancer: a population-based cohort study in Taiwan

doi:10.1002/alr.22526

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/24659

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/24659

Title:	Chronic rhinosinusitis after radiotherapy in patients with head and neck cancer: a population-based cohort study in Taiwan
Authors:	Lu, YT;Lu, YC;Cheng, HC;Hsin, CH;Yang, SF;Wang, PH;Yeh, HJ
Keywords:	chronic rhinosinusitis;head and neck cancer;radiotherapy;nationwide population-based cohort study;cancer;rhinosinusitis;surgery
Date:	2020
Issue Date:	2022-08-09T08:05:56Z (UTC)
Publisher:	WILEY
ISSN:	2042-6976
Abstract:	Background Chronic rhinosinusitis (CRS) is a common post-radiotherapy (RT) side effect in patients with nasopharyngeal cancer (NPC). However, whether RT is a risk factor for CRS in patients with other types of head and neck cancer remains unclear. This study investigated the association, if any, between CRS and RT in patients with head and neck cancer. Methods This retrospective cohort study included the data of patients newly diagnosed as having head and neck cancer between January 1, 2005, and December 31, 2008, from the 2005 Longitudinal Health Insurance Database. Patients were categorized into the following groups according to the treatment regimens received: RT alone (RT-alone), RT combined with other treatments (any-RT), and treatments without RT (no-RT). The outcome was the occurrence of CRS after treatment. Results Of the 701 patients, 7% experienced CRS within 5 years after initial treatment. Patients were divided into subgroups according to different treatment policies, and the RT-alone group, any-RT group, and no-RT group had 5-year incidence of CRS of 12%, 9.3%, and 4.5%, respectively. Patients in the RT-alone and any-RT groups exhibited an increased risk of CRS compared with patients in the no-RT group (hazard ratio: 6.76 and 2.91; 95% confidence interval: 2.60 to 17.5 and 1.60 to 5.31, respectively). Conclusion This is the first nationwide population-based cohort study to evaluate the risk of posttreatment CRS in patients with head and neck cancer. Our findings indicate that RT is a major risk factor for CRS. Thus, physicians should consider this potential risk in patients with head and neck cancer after RT.
URI:	http://dx.doi.org/10.1002/alr.22526 https://www.webofscience.com/wos/woscc/full-record/WOS:000513015100001 https://ir.csmu.edu.tw:8080/handle/310902500/24659
Relation:	INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY ,2020 ,v10 ,issue 5 ,p692-697
Appears in Collections:	[中山醫學大學研究成果] 期刊論文

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