Safety Assessment of HEA-EnrichedCordyceps cicadaeMycelium: A Randomized Clinical Trial

doi:10.1080/07315724.2020.1743211

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/24652

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/24652

Title:	Safety Assessment of HEA-EnrichedCordyceps cicadaeMycelium: A Randomized Clinical Trial
Authors:	Tsai, YS;Hsu, JH;Lin, DPC;Chang, HH;Chang, WJ;Chen, YL;Chen, CC
Keywords:	Cordyceps cicadae;N6-(2-hydroxyethyl) adenosine;clinical study;safety assessment;liquid fermentation
Date:	2021
Issue Date:	2022-08-09T08:05:49Z (UTC)
Publisher:	ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
ISSN:	0731-5724
Abstract:	Objective:Cordyceps cicadae, a medicinal fungus, is assessed as having many functions: anti-cancer, anti-fatigue, anti-aging, immune-boosting, renal and liver protection. Since the industrial production ofC. cicadaemycelium consistently manufactures bioactive compounds superior to wild fruiting bodies, there is a need to confirm the toxicity of liquid fermentedC. cicadaemycelium. Studies showed the toxicity evaluation ofC. cicadaemycelium in animal models, but safety reports in clinical studies are scarce. As such, a safety assessment of oral N6-(2-hydroxyethyl) adenosine (HEA-enriched)C. cicadaemycelium in humans is provided here. Method:After 49 participants ingested granules of 1.05 g of freeze-driedC. cicadaemycelium once a day for 3 months, their blood samples were collected at the beginning and end of the experiment for analysis. Results:There were no significant differences between the initial and final measurements in renal and liver function. Also, there was no influence on blood electrolytes as well as blood lipid levels. In clinical observation, there were also no side effects or adverse feelings mentioned by participants. Conclusion:These results suggested that HEA-enrichedC. cicadaemycelium produced by liquid fermentation is safe and can be developed as a functional health food.
URI:	http://dx.doi.org/10.1080/07315724.2020.1743211 https://www.webofscience.com/wos/woscc/full-record/WOS:000551334400001 https://ir.csmu.edu.tw:8080/handle/310902500/24652
Relation:	JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION ,2021 ,v40 ,issue 2 ,p127-132
Appears in Collections:	[中山醫學大學研究成果] 期刊論文

Files in This Item:

File	Description	Size	Format
index.html		0Kb	HTML	253	View/Open

Loading...