中山醫學大學機構典藏 CSMUIR:Item 310902500/24651
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    题名: Vitrectomy with internal limiting membrane peeling versus nonsurgical treatment for diabetic macular edema with massive hard exudates
    作者: Lin, HC;Yang, CM;Chen, SN;Hsieh, YT
    日期: 2020
    上传时间: 2022-08-09T08:05:48Z (UTC)
    出版者: PUBLIC LIBRARY SCIENCE
    ISSN: 1932-6203
    摘要: Purpose To compare the anatomical and functional outcomes of severe diabetic macular edema (DME) with massive hard exudates managed by pars plana vitrectomy (PPV) with internal limiting membrane (ILM) peeling or nonsurgical treatment. Methods We retrospectively reviewed 40 eyes with DME and massive hard exudates treated with either PPV with ILM peeling (vitrectomy group, 21 eyes) or nonsurgical treatment with anti-vascular endothelium growth factor (VEGF) and/or steroids (nonsurgical group, 19 eyes). Changes in best-corrected visual acuity (BCVA) and central retinal thickness (CRT) and resolution of macular hard exudates were compared between the two groups. Results After treatment, CRT decreased steadily in the vitrectomy group but fluctuated in the nonsurgical group. Compared with eyes in the nonsurgical group, eyes in the vitrectomy group had better visual improvement (P < 0.05 at 6 and 12 months and the final visit) and greater decrease in CRT (P < 0.05 at 3 and 6 months and the final visit) after adjustment for baseline BCVA. Hard exudates resolved more rapidly in the vitrectomy group than in the nonsurgical group, with 94.1% versus 47.4% eyes showing significant absorption after 6 months of the treatment (P = 0.003). In the vitrectomy group, 62% eyes did not require any further injections for treating DME after the operation. Conclusions PPV with ILM peeling resulted in rapid resolution of hard exudates with significant anatomical and functional improvement in DME with massive hard exudates.
    URI: http://dx.doi.org/10.1371/journal.pone.0236867
    https://www.webofscience.com/wos/woscc/full-record/WOS:000569367100054
    https://ir.csmu.edu.tw:8080/handle/310902500/24651
    關聯: PLOS ONE ,2020 ,v15 ,issue 7
    显示于类别:[中山醫學大學研究成果] 期刊論文

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