FGFR4 Gene Polymorphism Reduces the Risk of Distant Metastasis in Lung Adenocarcinoma in Taiwan

doi:10.3390/ijerph17165694

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/24635

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/24635

Title:	FGFR4 Gene Polymorphism Reduces the Risk of Distant Metastasis in Lung Adenocarcinoma in Taiwan
Authors:	Li, JP;Huang, HC;Yang, PJ;Chang, CY;Chao, YH;Tsao, TCY;Huang, H;Hung, YC;Hsieh, MJ;Yang, SF
Keywords:	lung cancer;FGFR4;polymorphism;EGFR mutation
Date:	2020
Issue Date:	2022-08-09T08:05:33Z (UTC)
Publisher:	MDPI
Abstract:	Fibroblast growth factor receptor 4 (FGFR4)is involved in multiple physiological and pathological processes. Several genetic variants ofFGFR4have been shown to be associated with tumor progression in many cancers. However, its association, such as genetic variants and expression levels, with lung cancer is controversial. The present study examined the relationship between four single-nucleotide polymorphisms (SNPs; rs2011077 T/C, rs351855 G/A, rs7708357 G/A, and rs1966265 A/G) ofFGFR4and the risk of lung adenocarcinoma with the epidermal growth factor receptor (EGFR) mutation status in a Taiwanese cohort. The results demonstrated thatFGFR4rs2011077 (odds ratio (OR) = 0.348, 95% confidence interval (CI) = 0.136-0.891,p= 0.024), and rs351855 (OR = 0.296, 95% CI = 0.116-0.751,p= 0.008) showed an inverse association with distant metastasis in wild-typeEGFRlung adenocarcinoma. Furthermore, a database analysis using The Cancer Genome Atlas revealed that the higherFGFR4expression level was correlated with poor survival rates in wild-typeEGFRlung adenocarcinoma. In conclusion, the data suggest thatFGFR4SNPs may help in identifying patient subgroups at low-risk for tumor metastasis, among carriers of lung adenocarcinoma bearing wild-typeEGFR.
URI:	http://dx.doi.org/10.3390/ijerph17165694 https://www.webofscience.com/wos/woscc/full-record/WOS:000565387900001 https://ir.csmu.edu.tw:8080/handle/310902500/24635
Relation:	INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH ,2020 ,v17 ,issue 16
Appears in Collections:	[中山醫學大學研究成果] 期刊論文

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