Fasting plasma glucose variability and HbA1c are associated with peripheral artery disease risk in type 2 diabetes

doi:10.1186/s12933-019-0978-y

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/24613

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/24613

Title:	Fasting plasma glucose variability and HbA1c are associated with peripheral artery disease risk in type 2 diabetes
Authors:	Yang, CP;Lin, CC;Li, CI;Liu, CS;Lin, CH;Hwang, KL;Yang, SY;Li, TC
Keywords:	HbA1c;Fasting plasma glucose;Glycemic variability;Peripheral artery disease
Date:	2020
Issue Date:	2022-08-09T08:05:12Z (UTC)
Publisher:	BMC
Abstract:	Background This study investigated whether visit-to-visit fasting plasma glucose (FPG) variability, as measured by the coefficient of variation (CV), increased peripheral artery disease (PAD) risk. Methods Individuals with type 2 diabetes from the National Diabetes Care Management Program during the period 2002-2004, >= 30 years of age, and free of PAD (n = 30,932) were included and monitored until 2011. Cox proportional hazards regression models were implemented to analyze related determinants of PAD. Results A total of 894 incident cases of PAD were identified during an average 8.2 years of follow-up, resulting in a crude incidence rate of 3.53 per 1000 person-years. Both FPG-CV and HbA1c were significantly associated with PAD after multivariate adjustment, with corresponding hazard ratios of 1.24 [95% confidence interval (CI) 1.04-1.47] for FPG-CV in the third tertile and 1.50 (95% CI 1.10-2.04) for HbA1c >= 10%. The findings of the sensitivity analysis remained consistent after excluding potential confounders, demonstrating the consistency of the results. Conclusions The associations between HbA1c, variability in FPG-CV, and PAD suggest a linked pathophysiological mechanism, suggesting the crucial role of glycemic variability in clinical management and therapeutic goals in preventing PAD in type 2 diabetes.
URI:	http://dx.doi.org/10.1186/s12933-019-0978-y https://www.webofscience.com/wos/woscc/full-record/WOS:000513914000005 https://ir.csmu.edu.tw:8080/handle/310902500/24613
Relation:	CARDIOVASCULAR DIABETOLOGY ,2020 ,v19 ,issue 1
Appears in Collections:	[中山醫學大學研究成果] 期刊論文

Files in This Item:

File	Description	Size	Format
index.html		0Kb	HTML	197	View/Open

Loading...