中山醫學大學機構典藏 CSMUIR:Item 310902500/24549
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    題名: Effects of Cajanus cajan (L.) millsp. roots extracts on the antioxidant and anti-inflammatory activities
    作者: Vo, TLT;Yang, NC;Yang, SE;Chen, CL;Wu, CH;Song, TY
    關鍵詞: Anti-inflammation;antioxidant;Cajanus cajan (L;) Millsp;root;uptake and genistein
    日期: 2020
    上傳時間: 2022-08-09T08:04:11Z (UTC)
    出版者: WOLTERS KLUWER MEDKNOW PUBLICATIONS
    ISSN: 0304-4920
    摘要: Cajanus cajan (L.) Millsp., also named pigeon pea, is widely grown in the tropics and the subtropics. C. cajan roots (CR) and ribs stewed in hot water have been used as a traditional medicine in various cultures to treat diabetes. The purpose of this study was to determine the functional components of hot water (WCR) and 50%, 95% ethanol extracts (EECR50 and EECR95) from CR, then evaluating their antioxidant and anti-inflammatory effects. The results indicated that EECR95 had higher polyphenol, especially the isoflavones (e.x. daidzein, genistein, and cajanol) than those of the other extracts, and it also exhibited the most potent anti-oxidative activities by in vitro antioxidant assay. In the lipopolysaccharide-stimulated RAW 264.7 cells, we found that EECR95 significantly decreased intracellular reactive oxygen species and significantly enhanced the activities of superoxide dismutase and catalase. Mechanism studies showed that EECR95 mainly activated nuclear factor (NF) erythroid 2-related factor 2/antioxidant protein heme oxygenase-1 and inhibited nuclear factor kappa B (NF-kappa B) signaling pathway, and thus exhibited antioxidant and anti-inflammatory effects. Overall, this study suggests that CR may have the potential to be developed as a biomedical material and that genistein, which has relatively high uptakes (3.44% for the pure compound and 1.73% for endogenous genistein of EECR95) at 24 h of incubation with RAW 264.7 cells, could be the main active component of CR.
    URI: http://dx.doi.org/10.4103/CJP.CJP_88_19
    https://www.webofscience.com/wos/woscc/full-record/WOS:000546028300006
    https://ir.csmu.edu.tw:8080/handle/310902500/24549
    關聯: CHINESE JOURNAL OF PHYSIOLOGY ,2020 ,v63 ,issue 3 ,p137-148
    顯示於類別:[中山醫學大學研究成果] 期刊論文

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