Purpose: To report the long-term prognosis of punctate inner choroidopathy (PIC) or multifocal choroiditis (MFC) and associated zonal outer retinopathy (ZOR). Method: Retrospective study in patients with PIC/MFC and ZOR with a clinical follow-up of 4 years or longer. Results: There were 14 patients in this study (M: F = 11:3). All patients received systemic steroid therapy. The initial and final median logarithm of minimal angle of resolution of BCVA were 1.00 and 0.22 (p = .002). Ellipsoid zone recovery was noted in all patients. The median visual field loss improved from -6.38 dB to -3.41 dB (p = .035). The median of total area of PIC/MFC lesions enlarged from 6.82 mm(2) to 8.77 mm(2) (p = .005). Recurrent disease was noted in 4 eyes and maintenance steroid was needed in 3 eyes. Conclusion: With steroid therapy, most patients with PIC/MFC and ZOR had good visual prognosis.
