中山醫學大學機構典藏 CSMUIR:Item 310902500/24497
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    题名: Mean and variability of annual haemoglobin A1c are associated with high-risk peripheral artery disease
    作者: Lee, IT
    关键词: Ankle-brachial index;haemoglobin A1c;percentage of the mean arterial pressure;peripheral artery disease;type 2 diabetes;variability
    日期: 2020
    上传时间: 2022-08-09T08:03:18Z (UTC)
    出版者: SAGE PUBLICATIONS LTD
    ISSN: 1479-1641
    摘要: Background: Glucose variability is predictive of cardiovascular events and all-cause mortality. However, the association between peripheral artery disease and glucose variability has not been thoroughly investigated. Therefore, the standard deviation of annual haemoglobin A1c was assessed in patients with type 2 diabetes for evaluating the different risks of peripheral artery disease. Methods: A total of 4144 patients underwent an evaluation for the ankle-brachial index and the percentage of mean arterial pressure at the ankle. The first haemoglobin A1c record was retrospectively collected from each year until the ankle-brachial index measurement. Results: The standard deviation of annual haemoglobin A1c was higher in patients with ankle-brachial index <= 0.90 than in those with ankle-brachial index >0.90 (1.1 +/- 0.9% vs 1.0 +/- 0.8%,p = 0.009) and was higher in patients with percentage of mean arterial pressure > 45% than in those with percentage of mean arterial pressure <45% (1.1 +/- 0.8% vs 1.0 +/- 0.8%,p = 0.007). A high standard deviation and mean of annual haemoglobin A1c are associated with high-risk peripheral artery disease, which is defined as a combination of ankle-brachial index <= 0.90, percentage of mean arterial pressure > 45% or both (odds ratio = 1.306; 95% confidence interval = 1.057-1.615;p = 0.014). Conclusion: Fluctuation in the haemoglobin A1c value indicates higher risk for peripheral artery disease in patients with type 2 diabetes and poor glucose control.
    URI: http://dx.doi.org/10.1177/1479164120909030
    https://www.webofscience.com/wos/woscc/full-record/WOS:000550038400001
    https://ir.csmu.edu.tw:8080/handle/310902500/24497
    關聯: DIABETES & VASCULAR DISEASE RESEARCH ,2020 ,v17 ,issue 3
    显示于类别:[中山醫學大學研究成果] 期刊論文

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