IGF2BP2 Polymorphisms Are Associated with Clinical Characteristics and Development of Oral Cancer

doi:10.3390/ijms21165662

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/24483

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/24483

Title:	IGF2BP2 Polymorphisms Are Associated with Clinical Characteristics and Development of Oral Cancer
Authors:	Chou, CH;Chang, CY;Lu, HJ;Hsin, MC;Chen, MK;Huang, HC;Yeh, CM;Lin, CW;Yang, SF
Keywords:	IGF2BP2;polymorphism;oral cancer;lymph node metastasis
Date:	2020
Issue Date:	2022-08-09T08:03:05Z (UTC)
Publisher:	MDPI
Abstract:	Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) is associated with insulin resistance, lipid metabolism, and tumorigenesis. However, the association between the IGF2BP2 polymorphism and oral cancer risk remains unclear. We recruited 1349 male patients with oral cancer and 1198 cancer-free controls. Three single nucleotide polymorphisms IGF2BP2 rs11705701, rs4402960, and rs1470579 were assessed using real-time polymerase chain reaction. The results indicate that the male patients with oral cancer and with the rs11705701 GA+AA, rs4402960 GT+TT, and rs1470579 AC+CC genotypes had increased risk of advanced clinical stage, larger tumor, and progression of lymph node metastasis compared with those with wild-type IGF2BP2. Moreover, according to The Cancer Genome Atlas dataset, high expression of the IGF2BP2 gene is associated with poor survival in patients with head and neck squamous cell carcinoma. In conclusion, our results suggest that IGF2BP2 polymorphisms are associated with less favorable oral cancer clinical characteristics.
URI:	http://dx.doi.org/10.3390/ijms21165662 https://www.webofscience.com/wos/woscc/full-record/WOS:000565609900001 https://ir.csmu.edu.tw:8080/handle/310902500/24483
Relation:	INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES ,2020 ,v21 ,issue 16
Appears in Collections:	[中山醫學大學研究成果] 期刊論文

Files in This Item:

File	Description	Size	Format
index.html		0Kb	HTML	154	View/Open

Loading...