Interaction of Osteoarthritis and BMI on Leptin Promoter Methylation in Taiwanese Adults

doi:10.3390/ijms21010123

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/24431

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/24431

Title:	Interaction of Osteoarthritis and BMI on Leptin Promoter Methylation in Taiwanese Adults
Authors:	Yang, TP;Chen, HM;Hu, CC;Chen, LY;Shih, FF;Tantoh, DM;Lee, KJ;Liaw, YC;Tsai, RT;Liaw, YP
Keywords:	BMI;LEP;obesity;methylation;osteoarthritis
Date:	2020
Issue Date:	2022-08-09T08:02:12Z (UTC)
Publisher:	MDPI
Abstract:	Leptin (LEP) regulates glucose metabolism and energy storage in the body. Osteoarthritis (OA) is associated with the upregulation of serum LEP. LEP promoter methylation is associated with obesity. So far, few studies have explored the association of BMI and OA with LEP methylation. We assessed the interaction between body mass index (BMI) and OA on LEP promoter methylation. Data of 1114 participants comprising 583 men and 558 women, aged 30-70 years were retrieved from the Taiwan Biobank Database (2008-2015). Osteoarthritis was self-reported and cases were those who reported having ever been clinically diagnosed with osteoarthritis. BMI was categorized into underweight, normal weight, overweight, and obesity. The mean LEP promoter methylation level in individuals with osteoarthritis was 0.5509 +/- 0.00437 and 0.5375 +/- 0.00101 in those without osteoarthritis. The interaction between osteoarthritis and BMI on LEP promoter methylation was significant (p-value = 0.0180). With normal BMI as the reference, the mean LEP promoter methylation level was significantly higher in obese osteoarthritic individuals (beta = 0.03696, p-value = 0.0187). However, there was no significant association between BMI and LEP promoter methylation in individuals without osteoarthritis, regardless of BMI. In conclusion, only obesity was significantly associated with LEP promoter methylation (higher levels) specifically in osteoarthritic patients.
URI:	http://dx.doi.org/10.3390/ijms21010123 https://www.webofscience.com/wos/woscc/full-record/WOS:000515378000123 https://ir.csmu.edu.tw:8080/handle/310902500/24431
Relation:	INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES ,2020 ,v21 ,issue 1
Appears in Collections:	[中山醫學大學研究成果] 期刊論文

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