中山醫學大學機構典藏 CSMUIR:Item 310902500/24428
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    题名: Quercetin attenuates cisplatin-induced fat loss
    作者: Lin, YC;Chen, LW;Chen, YC;Chan, ST;Liao, JW;Yeh, SL
    关键词: Cisplatin;Quercetin;Fat loss;Fat metabolism
    日期: 2021
    上传时间: 2022-08-09T08:02:09Z (UTC)
    出版者: SPRINGER HEIDELBERG
    ISSN: 1436-6207
    摘要: Purpose The major aim of the present study was to determine the effects of quercetin, a well-known flavonoid, on attenuating cisplatin (CDDP)-induced fat loss and the possible mechanisms. Methods Tumor-bearing nude mice and tumor-free BALB/c mice were administrated with CDDP alone or in combination with quercetin by a diet containing 0.1% or 1% quercetin (LQ or HQ) or by intraperitoneal injection (IQ) to determine the effects of quercetin on the anticancer effect of CDDP or CDDP-induced fat loss. The effects of quercetin on fat accumulation in CDDP-exposed 3T3-L1 cells were also determined. Results We first showed that HQ and IQ significantly enhanced the anticancer effect of CDDP by upregulating p53- and p21-associated pathways, while tended to attenuate CDDP-induced fat loss in tumor-bearing nude mice. The study in 3T3-L1 cells showed that CDDP decreased the fat accumulation accompanied by strong upregulation of the expression of six genes which are associated with fat metabolism, while quercetin completely suppressed such an effect. The tumor-free BALB/c mice study consistently showed a protective effect of HQ on CDDP-induced body weight and epididymal fat loss. HQ also increased the fat levels in liver and muscle tissues. In epididymal fat tissues, HQ consistently attenuated CDDP-induced changes in fat metabolism-associated gene expression. However, CDDP alone or in combination with HQ did not affect the food intake. Conclusions This study demonstrates that quercetin possesses the potential to suppress CDDP-induced fat loss may partly through the regulation of the fat metabolism-associated gene expression.
    URI: http://dx.doi.org/10.1007/s00394-020-02371-5
    https://www.webofscience.com/wos/woscc/full-record/WOS:000563603200001
    https://ir.csmu.edu.tw:8080/handle/310902500/24428
    關聯: EUROPEAN JOURNAL OF NUTRITION ,2021 ,v60 ,issue 4 ,p1781-1793
    显示于类别:[中山醫學大學研究成果] 期刊論文

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