Investigation of metastasis-associated in colon cancer-1 genetic variants in the development and clinicopathologcial characteristics of uterine cervical cancer in Taiwanese women

doi:10.7150/ijms.40204

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/24419

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/24419

Title:	Investigation of metastasis-associated in colon cancer-1 genetic variants in the development and clinicopathologcial characteristics of uterine cervical cancer in Taiwanese women
Authors:	Sun, YH;Chou, YH;Ou, CC;Ng, SC;Shen, HP;Lee, YC;Hsu, CF;Yang, SF;Wang, PH
Keywords:	metastasis-associated in colon cancer-1;single nucleotide polymorphisms;uterine cervical cancer;vaginal invasion;5 years survival rate
Date:	2020
Issue Date:	2022-08-09T08:01:59Z (UTC)
Publisher:	IVYSPRING INT PUBL
ISSN:	1449-1907
Abstract:	The objectives of this study were to define the associations among single nucleotide polymorphisms (SNPs) of metastasis-associated in colon cancer-1 (MACC1) gene, development and clinicopathological characteristics of uterine cervical cancer, and patient survival in Taiwan. Genotypic frequencies of 5 MACC1 SNPs rs975263, rs3095007, rs4721888, rs3735615 and rs1990172 were identified for 132 patients with invasive cancer, 99 with high-grade cervical intraepithelial neoplasia and 338 normal controls using real-time polymerase chain reaction. It revealed that there were no associations of these MACC1 SNPs with cervical carcinogenesis. In the meantime, cervical cancer patients with genotype GG in MACC1 SNP rs975263 tended to display more risk to have vaginal invasion than those with AA/AG (p=0.042, OR: 8.70, 95% CI: 0.81-433.22). In multivariate analysis, positive pelvic lymph node metastasis could significantly predict worse 5 years survival rate (p=0.001; HR=9.98, 95% CI=2.64-37.77) for cervical cancer patients. In conclusion, pelvic lymph node status rather than MACC1 SNPs was the only independent parameter that could significantly predict 5 years survival rate in Taiwanese women with cervical cancer.
URI:	http://dx.doi.org/10.7150/ijms.40204 https://www.webofscience.com/wos/woscc/full-record/WOS:000514851600008 https://ir.csmu.edu.tw:8080/handle/310902500/24419
Relation:	INTERNATIONAL JOURNAL OF MEDICAL SCIENCES ,2020 ,v17 ,issue 4 ,p490-497
Appears in Collections:	[中山醫學大學研究成果] 期刊論文

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