中山醫學大學機構典藏 CSMUIR:Item 310902500/24404
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    题名: Ochratoxin A triggered intracerebral hemorrhage in embryonic zebrafish: Involvement of microRNA-731 and prolactin receptor
    作者: Wu, TS;Lin, YT;Huang, YT;Yu, FY;Liu, BH
    关键词: Ochratoxin A;Intracerebral hemorrhage;Vascular defect;microRNA-731;Prolactin receptor a;Zebrafish embryos
    日期: 2020
    上传时间: 2022-08-09T08:01:44Z (UTC)
    出版者: PERGAMON-ELSEVIER SCIENCE LTD
    ISSN: 0045-6535
    摘要: Ochratoxin A (OTA), a mycotoxin widely found in foodstuffs, reportedly damages multiple brain regions in developing rodents, but the corresponding mechanisms have not been elucidated. In this study, zebrafish embryos at 6 h post fertilization (hpf) were exposed to various concentrations of OTA and the phenomenon associated with intracerebral hemorrhage was observed at 72 hpf. Exposure of embryos to OTA significantly increased their hemorrhagic rate in a dose-dependent manner. Large numbers of extravagated erythrocytes were observed in the midbrain/hindbrain areas of Tg(fli-1a:EGFP; gata1:DsRed) embryos following exposure to OTA. OTA also disrupted the vascular patterning, especially the arch-shaped central arteries (CtAs), in treated embryos. Histological analysis revealed a cavitylike pattern in their hindbrain ventricles, implying the possibility of cerebral edema. OTA-induced intracerebral hemorrhage and CtA vessel defects were partially reversed by the presence of miR-731 antagomir or the overexpression of prolactin receptor a (prlra); prlra is a downstream target of miR-731. These results suggest that exposure to OTA has a negative effect on cerebral vasculature development by interfering with the miR-731/PRLR axis in zebrafish. (C) 2019 Elsevier Ltd. All rights reserved.
    URI: http://dx.doi.org/10.1016/j.chemosphere.2019.125143
    https://www.webofscience.com/wos/woscc/full-record/WOS:000509786600041
    https://ir.csmu.edu.tw:8080/handle/310902500/24404
    關聯: CHEMOSPHERE ,2020 ,v242
    显示于类别:[中山醫學大學研究成果] 期刊論文

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