Tricetin Suppresses Migration and Presenilin-1 Expression of Nasopharyngeal Carcinoma through Akt/GSK-3 beta Pathway

doi:10.1142/S0192415X20500597

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/24385

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/24385

Title:	Tricetin Suppresses Migration and Presenilin-1 Expression of Nasopharyngeal Carcinoma through Akt/GSK-3 beta Pathway
Authors:	Ho, HY;Lin, FCF;Chen, PN;Chen, MK;Hsin, CH;Yang, SF;Lin, CW
Keywords:	Nasopharyngeal Carcinoma;Tricetin;Migration;Presenilin-1;Akt/GSK-3 beta
Date:	2020
Issue Date:	2022-08-09T08:01:27Z (UTC)
Publisher:	WORLD SCIENTIFIC PUBL CO PTE LTD
ISSN:	0192-415X
Abstract:	Lymph node migration results in poor prognoses for nasopharyngeal carcinoma (NPC) patients. Tricetin, a flavonoid derivative, regulates tumorigenesis activity through its antiproliferative and antimetastatic properties. However, the molecular mechanism of tricetin affecting the migration and invasion of NPC cells remains poorly understood. In this paper, we examined the antimetastatic properties of tricetin in human NPC cells. Our results demonstrated that tricetin at noncytotoxic concentrations (0-80 3M) noticeably reduced the migration and invasion of NPC cells (HONE-1, NPC-39, and NPC-BM). Moreover, tricetin suppressed the indicative protease, presenilin-1 (PS-1), as indicated by protease array. PS-1 was transcriptionally inhibited via the Akt signaling pathway but not mitogen-activated protein kinase pathways, such as the INK, p38, and ERK1/2 pathways. In addition to upregulating GSK-3 beta phosphorylation through Akt suppression, tricetin may downregulate the activity of PS-1. Overall, our study provides new insight into the role of tricetin-induced molecular regulation in the suppression of NPC metastasis and suggests that tricetin has prospective therapeutic applications for patients with NPC.
URI:	http://dx.doi.org/10.1142/S0192415X20500597 https://www.webofscience.com/wos/woscc/full-record/WOS:000551513000010 https://ir.csmu.edu.tw:8080/handle/310902500/24385
Relation:	AMERICAN JOURNAL OF CHINESE MEDICINE ,2020 ,v48 ,issue 5 ,p1203-1220
Appears in Collections:	[中山醫學大學研究成果] 期刊論文

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