Chronic Periodontitis Is Associated with the Risk of Bipolar Disorder: A Population-Based Cohort Study

doi:10.3390/ijerph17103466

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/24362

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/24362

Title:	Chronic Periodontitis Is Associated with the Risk of Bipolar Disorder: A Population-Based Cohort Study
Authors:	Huang, YK;Wang, YH;Chang, YC
Keywords:	bipolar disorder;chronic periodontitis;cohort study;Taiwan
Date:	2020
Issue Date:	2022-08-09T08:01:04Z (UTC)
Publisher:	MDPI
Abstract:	Bipolar disorder (BD) is a psychiatric mood disturbance manifested by manic, hypomanic, or major depressive periods. Chronic inflammation was evidenced as an important etiologic factor of BD. Chronic periodontitis (CP) is an inflammatory disease triggered by bacterial products, leading to the destruction of periodontium. The relationship between BD and CP is of interest to investigate. Therefore, a nationwide population-based cohort study was used to investigate the risk of BD and CP exposure from 2001 to 2012. We identified 61,608 patients with CP from the Taiwanese National Health Insurance Research Database (NHIRD). The 123,216 controls were randomly captured and matched by age, sex, index year, and co-morbidities. The association between CP exposure and BD risk was examined by Cox proportional hazards regression models. In this study, 61,608 CP patients and 123,216 controls were followed up for 7.45 and 7.36 years, respectively. In total, 138 BD patients were identified in the CP cohort and 187 BD cases were found in the non-CP cohort. The incidence rate of BD was significantly higher in the CP cohort than in the non-CP cohort (adjusted HR: 1.46, 95% CI: 1.17-1.81) according to the multivariate Cox regression analysis. Females had a 1.47-fold increased risk (95% CI: 1.16-1.86) for BD compared to males. Taken together, CP may be associated with an increased risk of subsequent BD in Taiwan.
URI:	http://dx.doi.org/10.3390/ijerph17103466 https://www.webofscience.com/wos/woscc/full-record/WOS:000539300900123 https://ir.csmu.edu.tw:8080/handle/310902500/24362
Relation:	INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH ,2020 ,v17 ,issue 10
Appears in Collections:	[中山醫學大學研究成果] 期刊論文

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