中山醫學大學機構典藏 CSMUIR:Item 310902500/24309
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    题名: Carbonic Anhydrase III Promotes Cell Migration and Epithelial-Mesenchymal Transition in Oral Squamous Cell Carcinoma
    作者: Chu, YH;Su, CW;Hsieh, YS;Chen, PN;Lin, CW;Yang, SF
    关键词: CA III;epithelial-mesenchymal transition;oral cancer;metastasis
    日期: 2020
    上传时间: 2022-08-09T08:00:12Z (UTC)
    出版者: MDPI
    摘要: Epithelial-mesenchymal transition (EMT) is strongly correlated with tumor metastasis and contains several protein markers, such as E-cadherin. Carbonic anhydrase III (CA III) exhibits low carbon dioxide hydratase activity in cancer. However, the detailed mechanisms of CA III and their roles in oral cancer are still unknown. This study established a CA III-overexpressed stable clone and observed the expression of CA III protein in human SCC-9 and SAS oral cancer cell lines. The migration and invasion abilities were determined using a Boyden chamber assay. Our results showed that the overexpression of CA III protein significantly increased the migration and invasion abilities in oral cancer cells. Moreover, a whole genome array analysis revealed that CA III regulated epithelial-mesenchymal transition by reducing the expression of epithelial markers. Data from the GEO database also demonstrated that CA III mRNA is negatively correlated with CDH1 mRNA. Mechanistically, CA III increased the cell motility of oral cancer cells through the FAK/Src signaling pathway. In conclusion, this suggests that CA III promotes EMT and cell migration and is potentially related to the FAK/Src signaling pathway in oral cancer.
    URI: http://dx.doi.org/10.3390/cells9030704
    https://www.webofscience.com/wos/woscc/full-record/WOS:000529337400181
    https://ir.csmu.edu.tw:8080/handle/310902500/24309
    關聯: CELLS ,2020 ,v9 ,issue 3
    显示于类别:[中山醫學大學研究成果] 期刊論文

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