The Impacts of Antivirals on the Coronavirus Genome Structure and Subsequent Pathogenicity, Virus Fitness and Antiviral Design

doi:10.3390/biomedicines8100376

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/24267

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/24267

Title:	The Impacts of Antivirals on the Coronavirus Genome Structure and Subsequent Pathogenicity, Virus Fitness and Antiviral Design
Authors:	Lin, CH;Yang, CY;Ou, SC;Wang, ML;Lo, CY;Tsai, TL;Wu, HY
Keywords:	coronavirus;genome structure;pathogenicity;remdesivir;innate immunity;antiviral drug;spike protein
Date:	2020
Issue Date:	2022-08-09T07:59:29Z (UTC)
Publisher:	MDPI
Abstract:	With the global threat of SARS-CoV-2, much effort has been focused on treatment and disease control. However, how coronaviruses react to the treatments and whether the surviving viruses have altered their characteristics are also unanswered questions with medical importance. To this end, bovine coronavirus (BCoV), which is in the same genus as SARS-CoV-2, was used as a test model and the findings were as follows. With the treatment of antiviral remdesivir, the selected BCoV variant with an altered genome structure developed resistance, but its pathogenicity was not increased in comparison to that of wild type (wt) BCoV. Under the selection pressure of innate immunity, the genome structure was also altered; however, neither resistance developed nor pathogenicity increased for the selected BCoV variant. Furthermore, both selected BCoV variants showed a better efficiency in adapting to alternative host cells than wt BCoV. In addition, the previously unidentified feature that the spike protein was a common target for mutations under different antiviral treatments might pose a problem for vaccine development because spike protein is a common target for antibody and vaccine designs. The findings derived from this fundamental research may contribute to the disease control and treatments against coronaviruses, including SARS-CoV-2.
URI:	http://dx.doi.org/10.3390/biomedicines8100376 https://www.webofscience.com/wos/woscc/full-record/WOS:000584472400001 https://ir.csmu.edu.tw:8080/handle/310902500/24267
Relation:	BIOMEDICINES ,2020 ,v8 ,issue 10
Appears in Collections:	[中山醫學大學研究成果] 期刊論文

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