中山醫學大學機構典藏 CSMUIR:Item 310902500/24233
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    题名: The potential remedy of melatonin on osteoarthritis
    作者: Lu, KH;Lu, PWA;Lu, EWH;Tang, CH;Su, SC;Lin, CW;Yang, SF
    关键词: anti-inflammation;antioxidant;apoptosis;melatonin;osteoarthritis
    日期: 2021
    上传时间: 2022-08-05T10:45:13Z (UTC)
    出版者: WILEY
    ISSN: 0742-3098
    摘要: Osteoarthritis (OA), the most common arthritis worldwide, is a degenerative joint disease characterized by progressive cartilage breakdown, subchondral remodeling, and synovial inflammation. Although conventional pharmaceutical therapies aimed to prevent further cartilage loss and joint dysfunction, there are no ideal strategies that target the pathogenesis of OA. Melatonin exhibits a variety of regulatory properties by binding to specific receptors and downstream molecules and exerts a myriad of receptor-independent actions via intracellular targets as a chondrocyte protector, an anti-inflammation modulator, and a free radical scavenger. Melatonin also modulates cartilage regeneration and degradation by directly/indirectly regulating the expression of main circadian clock genes, such as transcriptional activators [brain and muscle aryl hydrocarbon receptor nuclear translocator-like protein (Bmal) and circadian locomotor output cycles kaput (Clock)], transcriptional repressors [period circadian regulator (Per)1/2, cryptochrome (Cry)1/2, and Dec2], and nuclear hormone receptors [Rev-Erbs and retinoid acid-related orphan receptors (Rors)]. Owing to its effects on cartilage homeostasis, we propose a potential role for melatonin in the prevention and therapy of OA via the modulation of circadian clock genes, mitigation of chondrocyte apoptosis, anti-inflammatory activity, and scavenging of free radicals.
    URI: http://dx.doi.org/10.1111/jpi.12762
    https://www.webofscience.com/wos/woscc/full-record/WOS:000693252000001
    https://ir.csmu.edu.tw:8080/handle/310902500/24233
    關聯: JOURNAL OF PINEAL RESEARCH ,2021 ,v71 ,issue3
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