The potential remedy of melatonin on osteoarthritis

doi:10.1111/jpi.12762

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 其他文獻 > Item 310902500/24233

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/24233

Title:	The potential remedy of melatonin on osteoarthritis
Authors:	Lu, KH;Lu, PWA;Lu, EWH;Tang, CH;Su, SC;Lin, CW;Yang, SF
Keywords:	anti-inflammation;antioxidant;apoptosis;melatonin;osteoarthritis
Date:	2021
Issue Date:	2022-08-05T10:45:13Z (UTC)
Publisher:	WILEY
ISSN:	0742-3098
Abstract:	Osteoarthritis (OA), the most common arthritis worldwide, is a degenerative joint disease characterized by progressive cartilage breakdown, subchondral remodeling, and synovial inflammation. Although conventional pharmaceutical therapies aimed to prevent further cartilage loss and joint dysfunction, there are no ideal strategies that target the pathogenesis of OA. Melatonin exhibits a variety of regulatory properties by binding to specific receptors and downstream molecules and exerts a myriad of receptor-independent actions via intracellular targets as a chondrocyte protector, an anti-inflammation modulator, and a free radical scavenger. Melatonin also modulates cartilage regeneration and degradation by directly/indirectly regulating the expression of main circadian clock genes, such as transcriptional activators [brain and muscle aryl hydrocarbon receptor nuclear translocator-like protein (Bmal) and circadian locomotor output cycles kaput (Clock)], transcriptional repressors [period circadian regulator (Per)1/2, cryptochrome (Cry)1/2, and Dec2], and nuclear hormone receptors [Rev-Erbs and retinoid acid-related orphan receptors (Rors)]. Owing to its effects on cartilage homeostasis, we propose a potential role for melatonin in the prevention and therapy of OA via the modulation of circadian clock genes, mitigation of chondrocyte apoptosis, anti-inflammatory activity, and scavenging of free radicals.
URI:	http://dx.doi.org/10.1111/jpi.12762 https://www.webofscience.com/wos/woscc/full-record/WOS:000693252000001 https://ir.csmu.edu.tw:8080/handle/310902500/24233
Relation:	JOURNAL OF PINEAL RESEARCH ,2021 ,v71 ,issue3
Appears in Collections:	[中山醫學大學研究成果] 其他文獻

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