Association Between a History of Nontyphoidal Salmonella and the Risk of Systemic Lupus Erythematosus: A Population-Based, Case-Control Study

doi:10.3389/fimmu.2021.725996

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/24099

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/24099

Title:	Association Between a History of Nontyphoidal Salmonella and the Risk of Systemic Lupus Erythematosus: A Population-Based, Case-Control Study
Authors:	Tu, TY;Yeh, CY;Hung, YM;Chang, RN;Chen, HH;Wei, JCC
Keywords:	nontyphoidal Salmonella;systemic lupus erythematosus;NHIRD;case-control study;immunology;NTS;SLE;epidemiology
Date:	2021
Issue Date:	2022-08-05T09:47:48Z (UTC)
Publisher:	FRONTIERS MEDIA SA
ISSN:	1664-3224
Abstract:	ObjectiveWe investigated the correlation between nontyphoidal Salmonella (NTS) infection and systemic lupus erythematosus (SLE) risk. MethodsThis case-control study comprised 6,517 patients with newly diagnosed SLE between 2006 and 2013. Patients without SLE were randomly selected as the control group and were matched at a case-control ratio of 1:20 by age, sex, and index year. All study individuals were traced from the index date back to their NTS exposure, other relevant covariates, or to the beginning of year 2000. Conditional logistic regression analysis was used to analyze the risk of SLE with adjusted odds ratios (aORs) and 95% confidence intervals (CIs) between the NTS and control groups. ResultsThe mean age was 37.8 years in the case and control groups. Females accounted for 85.5%. The aOR of having NTS infection were significantly increased in SLE relative to controls (aOR, 9.20; 95% CI, 4.51-18.78) in 1:20 sex-age matching analysis and (aOR, 7.47; 95% CI=2.08-26.82) in propensity score matching analysis. Subgroup analysis indicated that the SLE risk was high among those who dwelled in rural areas; had rheumatoid arthritis, multiple sclerosis, or Sjogren's syndrome; and developed intensive and severe NTS infection during admission. ConclusionsExposure to NTS infection is associated with the development of subsequent SLE in Taiwanese individuals. Severe NTS infection and other autoimmune diseases such as rheumatoid arthritis, multiple sclerosis, or Sjogren's syndrome also contributed to the risk of developing SLE.
URI:	http://dx.doi.org/10.3389/fimmu.2021.725996 https://www.webofscience.com/wos/woscc/full-record/WOS:000727670100001 https://ir.csmu.edu.tw:8080/handle/310902500/24099
Relation:	FRONTIERS IN IMMUNOLOGY ,2021,v12
Appears in Collections:	[中山醫學大學研究成果] 期刊論文

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