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Please use this identifier to cite or link to this item:
https://ir.csmu.edu.tw:8080/ir/handle/310902500/24087
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Title: | Increased Risk of Retinal Vasculitis in Patients With Systemic Lupus Erythematosus: A Nationwide Population-Based Cohort Study |
Authors: | Chen, XH;Shi, JC;Wei, JCC;Chen, HH;Mo, HY |
Keywords: | retinal vasculitis;systemic lupus erythematosus;epidemiology;cohort study;database |
Date: | 2021 |
Issue Date: | 2022-08-05T09:47:36Z (UTC)
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Publisher: | FRONTIERS MEDIA SA |
Abstract: | Objectives: To evaluate the relationship between systemic lupus erythematosus (SLE) and the risk of retinal vasculitis (RV) using a population-based database. Methods: Using the 1997-2013 Taiwanese National Health Insurance Database, we identified newly diagnosed SLE patients between 2001 and 2012 as the SLE group. We matched the SLE group with non-SLE individuals selected from a representative one million sample of the population in a 1:20 ratio for age, sex, and the year of the index date. After adjusting for potential confounders, including urbanization of the patient's residence, the level of the payroll-related insured amount, and selected comorbidities, we examined the association between SLE and the risk of RV using the Cox proportional hazard model shown as hazard ratios (HRs) with 95% confidence intervals (CIs). Sensitivity analyses were conducted using various definitions of RV. Results: We included 11,586 patients with SLE and 231,720 matched non-SLE individuals. The mean age of the study participants was 36.7 +/- 16.9 years, and the female-to-male ratio was 6.8:1. The incidence rates of RV were 56.39 cases per 100,000 person-years and 2.45 cases per 100,000 person-years, respectively. After adjusting for potential confounders, the incidence rate of RV in the SLE cohort was 22.99 times higher than that in the non-SLE cohort (56.39 vs. 2.45 per 100,000 person-years). The adjusted HR for RV in the SLE group was 23.61 (95% CI, 14.94-37.32). The results remained robust in the sensitivity analysis. Conclusion: This nationwide population-based study revealed that SLE patients had a significantly higher risk of RV than non-SLE individuals. |
URI: | http://dx.doi.org/10.3389/fmed.2021.739883 https://www.webofscience.com/wos/woscc/full-record/WOS:000811950500001 https://ir.csmu.edu.tw:8080/handle/310902500/24087 |
Relation: | FRONTIERS IN MEDICINE ,2021,v8 |
Appears in Collections: | [中山醫學大學研究成果] 期刊論文
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