Non-Typhoidal Salmonella and the Risk of Kawasaki Disease: A Nationwide Population-Based Cohort Study

doi:10.3389/fimmu.2021.701409

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/24084

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/24084

Title:	Non-Typhoidal Salmonella and the Risk of Kawasaki Disease: A Nationwide Population-Based Cohort Study
Authors:	Chen, TYT;Chou, MC;Lai, JN;Chiu, LT;Chang, RN;Hung, YM;Wei, JCC
Keywords:	Cohort study;Non-typhoidal Salmonella;Kawasaki disease;NHIRD;Taiwan
Date:	2021
Issue Date:	2022-08-05T09:47:33Z (UTC)
Publisher:	FRONTIERS MEDIA SA
ISSN:	1664-3224
Abstract:	Objective The aim of this study was to investigate the relationship between non-typhoidal Salmonella (NTS) infection and the risk of Kawasaki disease (KD) by using a nationwide population-based data set in Taiwan. Methods In this retrospective cohort study, we enrolled 69,116 patients under 18 years of age, with NTS from January 1(st), 2000, to December 31(st), 2013, using the population-based National Health Insurance Research Database of Taiwan. A comparison group without NTS was matched (at a 1:4 ratio) by propensity score. The two cohorts were followed from the initial diagnosis of NTS until the date of KD development or December 31(st), 2013. Cox proportional hazard regression analysis was conducted to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) after adjusting for covariates. Also, we conducted sensitivity analyses to examine our findings. Results After adjusting for covariates, the risk of KD for the children with NTS was significantly higher than that of the comparison group (hazard ratio = 1.31; 95% confidence interval = 1.03-1.66; p < 0.01). Stratified analysis showed that the associated risk of the investigated outcome was significant in children aged <= 2 years (aHR= 1.31, 95% C.I. 1.02-1.69), in female patients (aHR= 1.46, 95% C.I. 1.03-2.08), and in those without allergic diseases. Conclusions NTS is associated with an increased risk of KD in Taiwanese children.
URI:	http://dx.doi.org/10.3389/fimmu.2021.701409 https://www.webofscience.com/wos/woscc/full-record/WOS:000669027200001 https://ir.csmu.edu.tw:8080/handle/310902500/24084
Relation:	FRONTIERS IN IMMUNOLOGY ,2021,v12
Appears in Collections:	[中山醫學大學研究成果] 期刊論文

Files in This Item:

File	Description	Size	Format
index.html		0Kb	HTML	190	View/Open

Loading...