Obstructive sleep apnea and influenza infection: a nationwide population-based cohort study

doi:10.1016/j.sleep.2021.02.034

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/24068

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/24068

Title:	Obstructive sleep apnea and influenza infection: a nationwide population-based cohort study
Authors:	Chen, TYT;Chang, RN;Chiu, LT;Hung, YM;Wei, JCC
Keywords:	Obstructive sleep apnea (OSA);Influenza;Cohort study;Taiwan national health insurance research database (NHIRD)
Date:	2021
Issue Date:	2022-08-05T09:47:20Z (UTC)
Publisher:	ELSEVIER
ISSN:	1389-9457
Abstract:	Objectives: Influenza infection could trigger acute myocardial infarction. Obstructive sleep apnea (OSA) increases risk for myocardial infarction. Evidence evaluating the risk of influenza in patients with OSA is limited. We aimed to investigate the association between OSA and influenza using a nationwide population-based data set. Methods: A total of 5483 individuals with OSA were enrolled from January, 2000, to December, 2012, and compared with a control group of 21,932 individuals who had never been diagnosed with OSA (at a 1:4 ratio propensity score matched by age, sex, index years, and comorbidities) in the context of subsequent influenza infection. Cox proportional hazard regression analysis was conducted to analyze the association between OSA and influenza incidence. We conducted sensitivity analyses to examine our finding. Results: During the 1.81 (+/- 2.12) years of the follow-up period, the incidence rate of influenza infection was higher in the OSA group compared with the non-OSA group (36.40 and 30.09 per 100 person-years). After adjusting for age, sex, comorbidities, outpatients visits, the risk of influenza infection among patients with OSA was significantly higher (hazard ratio = 1.18; 95% confidence interval = 1.14-1.23; P < 0.001). Sensitivity analyses showed consistent positive association. Males with OSA had increased risk of influenza infection compared with males without OSA (adjusted HR, 1.21; 95% CI, 1.16-1.27; P value for interaction = 0.03). Conclusions: This study found a significantly higher risk of influenza infection in patients with OSA, and sex acted as an effect modifier between OSA and risk of influenza infection. (C) 2021 Elsevier B.V. All rights reserved.
URI:	http://dx.doi.org/10.1016/j.sleep.2021.02.034 https://www.webofscience.com/wos/woscc/full-record/WOS:000646006300029 https://ir.csmu.edu.tw:8080/handle/310902500/24068
Relation:	SLEEP MEDICINE ,2021,v81 , P202-209
Appears in Collections:	[中山醫學大學研究成果] 期刊論文

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