Association Between Subconjunctival Hemorrhage and Acute Coronary Syndrome: A 14-Year Nationwide Population-Based Cohort Study

doi:10.3389/fcvm.2021.728570

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/24031

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/24031

Title:	Association Between Subconjunctival Hemorrhage and Acute Coronary Syndrome: A 14-Year Nationwide Population-Based Cohort Study
Authors:	Chiang, PH;Lai, JN;Chiang, YC;Hu, KC;Hsu, MY;Wei, JCC
Keywords:	subconjunctival hemorrhage;acute coronary syndrome;population-based cohort study;Taiwan National Health Insurance Research Database;aspirin
Date:	2021
Issue Date:	2022-08-05T09:46:45Z (UTC)
Publisher:	FRONTIERS MEDIA SA
ISSN:	2297-055X
Abstract:	Purpose: Subconjunctival hemorrhage (SCH) is usually a benign ocular disorder that causes painless, redness under the conjunctiva. However, since SCH and acute coronary syndrome (ACS) share many vascular risk factors, studies have suggested that these two disorders may be significantly associated with each other, and evaluate the concomitance of ACS in patients with SCH. Methods: This population-based cohort study, enrolled 35,260 Taiwanese patients, and used the Taiwan National Health Insurance Research Database to identify patients with ACS and SCH. Outcomes were compared between the with and without SCH groups. The study population was followed until the date of ACS onset, the date of withdrawal, death, or December 31st 2013, whichever came first. Results: Of the 85,925 patients identified with SCH between 1996 and 2013, 68,295 were excluded based on the study's exclusion criteria, and a total of 17,630 patients with SCH who were diagnosed by ophthalmologists between 2000 and 2012 were eligible for analysis. After 1:1 propensity score matching for 5-year age groups, gender, and the index year, the results showed that SCH was more common in the 40-59 age group (53.82%) and females (58.66%). As for the ACS-related risk factors, patients with diabetes mellitus (aHR = 1.58, 95% CI = [1.38, 1.81]), hypertension (aHR = 1.71, 95% CI = [1.49, 1.96]) and patients taking aspirin (aHR = 1.67, 95% CI = [1.47, 1.90]) had a notably higher risk of ACS. However, it was found that there were no significant differences in the occurrence of ACS between the non-SCH and SCH patients. Conclusion: This results of this study regarding the risk factors and epidemiology of SCH and ACS were in keeping with previously reported findings. However, the results revealed no significant association between SCH and ACS.
URI:	http://dx.doi.org/10.3389/fcvm.2021.728570 https://www.webofscience.com/wos/woscc/full-record/WOS:000709085700001 https://ir.csmu.edu.tw:8080/handle/310902500/24031
Relation:	FRONTIERS IN CARDIOVASCULAR MEDICINE ,2021,v8
Appears in Collections:	[中山醫學大學研究成果] 期刊論文

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