Water composed of reduced hydrogen bonds activated by localized surface plasmon resonance effectively enhances anti-viral and anti-oxidative activities of melatonin

doi:10.1016/j.cej.2021.131626

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/24021

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/24021

Title:	Water composed of reduced hydrogen bonds activated by localized surface plasmon resonance effectively enhances anti-viral and anti-oxidative activities of melatonin
Authors:	Renn, TY;Yang, CP;Wu, UI;Chen, LY;Mai, FD;Tikhonova, MA;Amstislavskaya, TG;Liao, WC;Lin, CT;Liu, YC;Chang, HM
Keywords:	Anti-oxidative effects;Anti-viral function;Melatonin;Plasmon-activated water;Biomedical application;Hepatic bioenergetics
Date:	2021
Issue Date:	2022-08-05T09:46:33Z (UTC)
Publisher:	ELSEVIER SCIENCE SA
ISSN:	1385-8947
Abstract:	Melatonin is a lipophilic antioxidant generally dissolved in organic solvent before delivery. However, the presence of organics may severely depress the functional effects of melatonin. By rendering deionized water (DIW) flow through gold nano-particles under localized surface plasmon resonant illumination, we developed plasmon-activated water (PAW) which successfully increases the solubility of melatonin to 150.325%. Melatonin dissolved in PAW also exhibits stronger anti-viral and anti-oxidative activities than that dissolved in DIW in which the percentage of dengue virus infected human hepatocellular carcinoma cells is remarkably decreased (14.7% vs. 20.6%) whilst the clearance rate of hydroxyl radical is significantly enhanced (11.9% vs. 6.69%), respectively. Moreover, in vivo approaches further show that following chronic sleep deprivation, the level of oxidative stress, hepatic bioenergetics, anti-oxidative enzyme activity, and metabolic function are all significantly improved in rats received melatonin prepared in PAW than that in DIW. As the bio-activity of melatonin depends largely on its solubility, utilizing PAW as a non-organic solvent will not only enhance the anti-viral and anti-oxidative function of melatonin, but also offer great potential for clinical use of melatonin as a therapeutic strategy to depress virus infection and counteract oxidative damage in a more natural, more economic and more efficient way.
URI:	http://dx.doi.org/10.1016/j.cej.2021.131626 https://www.webofscience.com/wos/woscc/full-record/WOS:000727778600003 https://ir.csmu.edu.tw:8080/handle/310902500/24021
Relation:	CHEMICAL ENGINEERING JOURNAL ,2022,v427
Appears in Collections:	[中山醫學大學研究成果] 期刊論文

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