Timing, Dosage, and Adherence of Antiretroviral Therapy and Risk of Osteoporosis in Patients With Human Immunodeficiency Virus Infection in Taiwan: A Nested Case-Control Study

doi:10.3389/fphar.2021.631480

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/24018

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题名:	Timing, Dosage, and Adherence of Antiretroviral Therapy and Risk of Osteoporosis in Patients With Human Immunodeficiency Virus Infection in Taiwan: A Nested Case-Control Study
作者:	Chiu, ML;Liang, WM;Li, JP;Cheng, CF;Chiou, JS;Ho, MW;Wu, YC;Lin, TH;Liao, CC;Huang, SM;Tsai, FJ;Lin, YJ
关键词:	HIV;osteoporosis;antiretroviral therapy;usage timing;dosage;adherence
日期:	2021
上传时间:	2022-08-05T09:46:31Z (UTC)
出版者:	FRONTIERS MEDIA SA
摘要:	The progression of acquired immunodeficiency syndrome is delayed in patients with human immunodeficiency virus (HIV) infection receiving antiretroviral therapy (ART). However, long-term ART is associated with adverse effects. Osteoporosis is one of the adverse effects and is a multifactorial systemic skeletal disease associated with bone fragility and an increased risk of fracture. We performed a longitudinal, comprehensive, nested case-control study to explore the effect of ART on the risk of osteoporosis in 104 osteoporotic and 416 non-osteoporotic patients with HIV infection at their average age about 29 years old in Taiwan. Patients with history of ART, current exposure to ART, higher cumulative defined daily doses (DDDs), or higher ART adherence were at a higher risk of osteoporosis (p < 0.05). Patients receiving nucleoside/nucleotide reverse transcriptase inhibitor (NRTI)-containing regimen (zidovudine-lamivudine combination, lamivudine-abacavir combination, and abacavir alone) and protease inhibitor (PI)-containing regimen (lopinavir-ritonavir combination, ritonavir, and atazanavir) had a higher risk of osteoporosis (p < 0.05). Especially, patients receiving high doses of the PIs lopinavir-ritonavir combination had an increased risk of osteoporosis (p < 0.05). In conclusion, history of ART, current exposure to ART, higher cumulative DDDs, and higher ART adherence were associated with an increased risk of osteoporosis. Furthermore, NRTI- and PI-containing regimens and high doses of PIs lopinavir-ritonavir combination may be associated with an increased risk of osteoporosis in patients with HIV infection in Taiwan.
URI:	http://dx.doi.org/10.3389/fphar.2021.631480 https://www.webofscience.com/wos/woscc/full-record/WOS:000650015500001 https://ir.csmu.edu.tw:8080/handle/310902500/24018
關聯:	FRONTIERS IN PHARMACOLOGY ,2021,v12
显示于类别:	[中山醫學大學研究成果] 期刊論文

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