Risk of Autoimmune Diseases in Patients With Interstitial Cystitis/Bladder Pain Syndrome: A Nationwide Population-Based Study in Taiwan

doi:10.3389/fmed.2021.747098

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/23950

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/23950

Title:	Risk of Autoimmune Diseases in Patients With Interstitial Cystitis/Bladder Pain Syndrome: A Nationwide Population-Based Study in Taiwan
Authors:	Yueh, HZ;Yang, MH;Huang, JY;Wei, JCC
Keywords:	autoimmune diseases;interstitial cystitis;bladder pain syndrome;cohort study;nationwide population
Date:	2021
Issue Date:	2022-08-05T09:45:26Z (UTC)
Publisher:	FRONTIERS MEDIA SA
Abstract:	Objective: The association between autoimmune diseases (ADs) and interstitial cystitis/bladder pain syndrome (IC/BPS) has long been investigated. However, the lack of comprehensive descriptions of patients in the literature has made comparison and evaluation impossible. We aim to investigate the risk of systemic ADs in patients with IC/BPS in Taiwan using a population-based administrative database. Methods: This study evaluated 1,095 patients newly diagnosed with IC/BPS between 2000 and 2013, using data from Taiwan's National Health Insurance Research Database. These patients were randomly matched by demographic characteristics with a comparison cohort of individuals without IC/BPS at a ratio of 1:20. Cox proportional hazards regression analysis was used to analyze the risk of ADs, adjusting for age, sex, urbanization, length of hospital stay, and comorbidities adjustment. Sensitivity analysis by propensity score was used to adjust for confounding factors. Results: The adjusted Hazard Ratio (aHR) of ADs for IC/BPS patients was 1.409 (95% CI 1.152-1.725). The subgroup analysis indicated that female or 45-60 years of age had a greater risk of ADs. Furthermore, the subgroup analysis of primary outcomes indicated that IC/BPS had greater incidence with Hashimoto's thyroiditis (aHR = 2.767, 95% CI 1.039-7.368), ankylosing spondylitis (aHR = 2.429, 95% CI 1.264-4.67), rheumatoid arthritis (aHR = 1.516, 95% CI 1.001-2.296), and Sjogren's syndrome (aHR = 1.962, 95% CI 1.37-2.809). Conclusion: IC/BPS was associated with the development of ADs in our study population, especially Hashimoto's thyroiditis, ankylosing spondylitis, rheumatoid arthritis, and Sjogren's syndrome. Clinicians are recommended to be alert to the increased likelihood of developing ADs, particularly for middle-aged women.
URI:	http://dx.doi.org/10.3389/fmed.2021.747098 https://www.webofscience.com/wos/woscc/full-record/WOS:000702945000001 https://ir.csmu.edu.tw:8080/handle/310902500/23950
Relation:	FRONTIERS IN MEDICINE ,2021,v8
Appears in Collections:	[中山醫學大學研究成果] 期刊論文

Files in This Item:

File	Description	Size	Format
index.html		0Kb	HTML	232	View/Open

Loading...