Association of Hematuria with Renal Progression and Survival in Patients Who Underwent Living Donor Liver Transplant

doi:10.3390/jcm10194345

中山醫學大學機構典藏 CSMUIR > 中山醫學大學研究成果 > 期刊論文 > Item 310902500/23859

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/23859

Title:	Association of Hematuria with Renal Progression and Survival in Patients Who Underwent Living Donor Liver Transplant
Authors:	Chang, KC;Hsieh, YP;Chao, HN;Lin, CM;Lin, KH;Tsai, CC;Heish, CE;Lin, PR;Kor, CT;Chen, YL;Chiu, PF
Keywords:	liver transplantation;hematuria;chronic kidney disease;survival
Date:	2021
Issue Date:	2022-08-05T09:44:02Z (UTC)
Publisher:	MDPI
Abstract:	Background: This study aimed to determine the association between episodic or persistent hematuria after liver transplantation and long-term renal outcomes. Methods: Patients who underwent living donor liver transplantation between July 2005 and June 2019 were recruited and divided into two groups based on the finding of microscopic or gross hematuria after transplantation. All patients were followed up from the index date until the end date in May 2020. The risks of chronic kidney disease, death, and 30% and 50% declines in estimated glomerular filtration rate (eGFR) were compared between groups. Results: A total of 295 patients underwent urinalysis for various reasons after undergoing transplantation. Hematuria was detected in 100 patients (group A) but was not present in 195 patients (group B). Compared with group B, group A had a higher risk of renal progression, including eGFR decline > 50% [aHR = 3.447 (95%CI: 2.24~5.30), p < 0.001] and worse survival. In addition, patients who took non-steroidal anti-inflammatory drugs (NSAIDs) continuously for over seven days within six months before transplant surgery had high risks of rapid renal progression, including a > 30% decline in eGFR [aHR = 1.572 (95%CI: 1.12~2.21), p = 0.009)]. Conclusion: Development of hematuria after surgery in patients who underwent living donor liver transplant and were exposed to NSAIDs before surgery were associated with worse long-term renal dysfunction and survival.
URI:	http://dx.doi.org/10.3390/jcm10194345 https://www.webofscience.com/wos/woscc/full-record/WOS:000725464400001 https://ir.csmu.edu.tw:8080/handle/310902500/23859
Relation:	JOURNAL OF CLINICAL MEDICINE ,2021,v10,issue 19
Appears in Collections:	[中山醫學大學研究成果] 期刊論文

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